Nocito Marta Claudia, De Luca Arianna, Prestia Francesca, Avena Paola, La Padula Davide, Zavaglia Lucia, Sirianni Rosa, Casaburi Ivan, Puoci Francesco, Chimento Adele, Pezzi Vincenzo
Department of Pharmacy and Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, Arcavacata di Rende, 87036 Cosenza, Italy.
Biomedicines. 2021 Oct 14;9(10):1476. doi: 10.3390/biomedicines9101476.
Curcumin, a main bioactive component of the L. rhizome, is a phenolic compound that exerts a wide range of beneficial effects, acting as an antimicrobial, antioxidant, anti-inflammatory and anticancer agent. This review summarizes recent data on curcumin's ability to interfere with the multiple cell signaling pathways involved in cell cycle regulation, apoptosis and the migration of several cancer cell types. However, although curcumin displays anticancer potential, its clinical application is limited by its low absorption, rapid metabolism and poor bioavailability. To overcome these limitations, several curcumin-based derivatives/analogues and different drug delivery approaches have been developed. Here, we also report the anticancer mechanisms and pharmacokinetic characteristics of some derivatives/analogues and the delivery systems used. These strategies, although encouraging, require additional in vivo studies to support curcumin clinical applications.
姜黄素是姜黄根茎的主要生物活性成分，是一种酚类化合物，具有广泛的有益作用，可作为抗菌、抗氧化、抗炎和抗癌剂。本综述总结了姜黄素干扰参与细胞周期调控、凋亡和几种癌细胞类型迁移的多种细胞信号通路的能力的最新数据。然而，尽管姜黄素具有抗癌潜力，但其临床应用受到低吸收、快速代谢和低生物利用度的限制。为了克服这些限制，已经开发了几种基于姜黄素的衍生物/类似物和不同的药物递送方法。在此，我们还报告了一些衍生物/类似物以及所用递送系统的抗癌机制和药代动力学特征。这些策略虽然令人鼓舞，但需要更多的体内研究来支持姜黄素的临床应用。
