硬度很重要：柔软的骨髓类器官可使造血干细胞恢复活力。
Stiffness matters: A soft bone marrow organoid rejuvenates hematopoietic stem cells.
作者信息
Zhang Xiaoying, Yue Rui
机构信息
Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
出版信息
Mechanobiol Med. 2023 Jul 5;1(1):100009. doi: 10.1016/j.mbm.2023.100009. eCollection 2023 Sep.
A recent study published in [1] showed that matrix stiffness critically regulates hematopoietic stem cell (HSC) niche, and successfully engineered a soft bone marrow (BM) organoid to maintain and rejuvenate HSCs . In addition, BM stiffening was also identified as a novel aging hallmark of the hematopoietic system. Together, these important findings implicate matrix stiffness as a fundamental biomechanical factor governing cell fate determination and aging of tissue-specific stem cells.
最近发表在[1]上的一项研究表明，基质硬度对造血干细胞（HSC）微环境起着关键调节作用，并成功构建了一种软骨髓类器官来维持造血干细胞并使其恢复活力。此外，骨髓硬化也被确定为造血系统的一种新的衰老标志。这些重要发现共同表明，基质硬度是决定组织特异性干细胞命运和衰老的一个基本生物力学因素。
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