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Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation.
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2
Phenotypic alteration of bone marrow HSC and microenvironmental association in experimentally induced leukemia.
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Microenvironmental regulation of hematopoietic stem cells and its implications in leukemogenesis.
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Hematopoietic and Leukemic Stem Cells Have Distinct Dependence on Tcf1 and Lef1 Transcription Factors.
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Epigenetic dysregulation of hematopoietic stem cells and preleukemic state.
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Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions.
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Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches.
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Complexity of bone marrow hematopoietic stem cell niche.
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Exosome-mediated microenvironment dysregulation in leukemia.
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Age-associated changes in human hematopoietic stem cells.
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Regenerating aged bone marrow via a nitric oxide nanopump.
Nat Commun. 2025 Jul 1;16(1):5677. doi: 10.1038/s41467-025-61256-5.
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Global, regional, and national burden of leukemia: Epidemiological trends analysis from 1990 to 2021.
PLoS One. 2025 Jun 26;20(6):e0325937. doi: 10.1371/journal.pone.0325937. eCollection 2025.
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Stiffness matters: A soft bone marrow organoid rejuvenates hematopoietic stem cells.
Mechanobiol Med. 2023 Jul 5;1(1):100009. doi: 10.1016/j.mbm.2023.100009. eCollection 2023 Sep.
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The role of genetic/epigenetic factors and microenvironment in hematopoietic stem cell ageing.
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Decoding functional hematopoietic progenitor cells in the adult human lung.
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Aging and Cancer-Inextricably Linked Across the Lifespan.
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models of leukemia development: the role of very small leukemic stem-like cells in the cellular transformation cascade.
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Adult skull bone marrow is an expanding and resilient haematopoietic reservoir.
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Age-associated imbalance in immune cell regeneration varies across individuals and arises from a distinct subset of stem cells.
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本文引用的文献

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The global clonal complexity of the murine blood system declines throughout life and after serial transplantation.
Blood. 2019 May 2;133(18):1927-1942. doi: 10.1182/blood-2018-09-873059. Epub 2019 Feb 19.
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Heterogeneous Responses of Hematopoietic Stem Cells to Inflammatory Stimuli Are Altered with Age.
Cell Rep. 2018 Dec 11;25(11):2992-3005.e5. doi: 10.1016/j.celrep.2018.11.056.
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Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level.
Nat Med. 2019 Jan;25(1):103-110. doi: 10.1038/s41591-018-0267-4. Epub 2018 Dec 3.
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The obese adipose tissue microenvironment in cancer development and progression.
Nat Rev Endocrinol. 2019 Mar;15(3):139-154. doi: 10.1038/s41574-018-0126-x.
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Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005.
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Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia.
Nat Med. 2018 Dec;24(12):1859-1866. doi: 10.1038/s41591-018-0233-1. Epub 2018 Nov 12.

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