McConnaha Elizabeth, Giles Jennifer, Wauson Eric, Tran Quang-Kim
Department of Physiology & Pharmacology, Des Moines University College of Osteopathic Medicine 3200 Grand Avenue, Des Moines, IA 50312, USA.
Autophagy Rep. 2022 May 1;1(1):201-204. doi: 10.1080/27694127.2022.2069969. eCollection 2022.
Macroautophagy/autophagy is a process that degrades unnecessary cellular components to maintain homeostasis. The Ca-sensing protein CALM (calmodulin) is needed for many cell functions yet is a limiting factor because of its insufficient availability for its target proteins. Although Ca produces diverse actions in autophagy, the role of CALM in autophagy at basal conditions, when there is no external stimulation for increases in intracellular Ca, is not known. Our recent work indicates that CALM availability is critical for basal autophagy. In this punctum, we summarize our findings and discuss mechanisms whereby CALM regulates basal autophagy.
巨自噬/自噬是一个降解不必要细胞成分以维持体内平衡的过程。钙传感蛋白CALM（钙调蛋白）参与许多细胞功能，但由于其对靶蛋白的可利用性不足，它是一个限制因素。尽管钙在自噬中产生多种作用，但在基础条件下，即没有外部刺激导致细胞内钙增加时，CALM在自噬中的作用尚不清楚。我们最近的研究表明，CALM的可利用性对基础自噬至关重要。在本小节中，我们总结了我们的发现，并讨论了CALM调节基础自噬的机制。
