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Beyond the dose: rethinking ketamine neurotoxicity in critical illness.

作者信息

Liao Rongqiang, Zheng Xiaoyuan

机构信息

Pharmacy Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, China.

出版信息

Intensive Care Med. 2025 May 21. doi: 10.1007/s00134-025-07951-9.

DOI:10.1007/s00134-025-07951-9
PMID:40397126
Abstract
摘要

相似文献

1
Beyond the dose: rethinking ketamine neurotoxicity in critical illness.超越剂量:重新审视危重症中的氯胺酮神经毒性
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N-Acetylcysteine Mitigates Ketamine Neurotoxicity in Young Rats by Modulating ROS-Mediated Pyroptosis and Ferroptosis.N-乙酰半胱氨酸通过调节活性氧介导的细胞焦亡和铁死亡减轻幼鼠氯胺酮神经毒性。
Mol Neurobiol. 2025 Mar 20. doi: 10.1007/s12035-025-04860-2.
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Protective effects of curcumin/magnesium oxide nanoparticles on ketamine-induced neurotoxicity in the mouse hippocampus.姜黄素/氧化镁纳米颗粒对氯胺酮诱导的小鼠海马神经毒性的保护作用。
Res Pharm Sci. 2025 Jun 17;20(3):416-433. doi: 10.4103/RPS.RPS_5_23. eCollection 2025 Jun.
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Br J Anaesth. 2011 Oct;107(4):601-11. doi: 10.1093/bja/aer258. Epub 2011 Aug 16.
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Association of low-dose ketamine with hallucinations in critically ill patients: a target trial emulation.低剂量氯胺酮与危重症患者幻觉的关联:一项目标试验模拟研究
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Ketamine for Analgosedation in the Intensive Care Unit: A Systematic Review.氯胺酮在重症监护病房中的镇静作用:系统评价。
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Ketamine Analgo-sedation for Mechanically Ventilated Critically Ill Adults: A Rapid Practice Guideline from the Saudi Critical Care Society and the Scandinavian Society of Anesthesiology and Intensive Care Medicine.氯胺酮用于机械通气的危重症成年患者的镇痛镇静:沙特重症监护学会和斯堪的纳维亚麻醉与重症监护医学学会的快速实践指南。
Anesth Analg. 2024 Aug 29. doi: 10.1213/ANE.0000000000007173.

本文引用的文献

1
Association of low-dose ketamine with hallucinations in critically ill patients: a target trial emulation.低剂量氯胺酮与危重症患者幻觉的关联:一项目标试验模拟研究
Intensive Care Med. 2025 May 5. doi: 10.1007/s00134-025-07926-w.
2
Hallucinations and disturbed behaviour in the critically ill: incidence, patient characteristics, associations, trajectory, and outcomes.危重症患者的幻觉与行为紊乱:发生率、患者特征、关联因素、病程及结局
Crit Care. 2025 Jan 31;29(1):54. doi: 10.1186/s13054-025-05290-1.
3
Neurological complications of sepsis.脓毒症的神经系统并发症。
Curr Opin Crit Care. 2023 Apr 1;29(2):75-84. doi: 10.1097/MCC.0000000000001022. Epub 2023 Feb 15.
4
Ketamine Pharmacokinetics.氯胺酮药代动力学。
Anesthesiology. 2020 Dec 1;133(6):1192-1213. doi: 10.1097/ALN.0000000000003577.
5
Ketamine for analgosedation in critically ill patients.氯胺酮用于危重症患者的镇痛镇静
J Crit Care. 2016 Oct;35:145-9. doi: 10.1016/j.jcrc.2016.05.016. Epub 2016 May 25.