Tan Yi-Ling, Qu Rui, Zhang Wei-Qian, Tang Dong-Dong, Yang Jing, Li Xing
Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Reproductive Medicine Center, Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Curr Med Sci. 2025 May 21. doi: 10.1007/s11596-025-00063-x.
Heat wave exposure significantly impacts human health. Nevertheless, studies on the long-term effects of heat wave exposure during adolescence on adverse pregnancy outcomes (APOs) are rare. This study aimed to investigate the relationship between the long-term effects of heat wave exposure during adolescence and APOs.
We analyzed data from 3,376 female and 3,013 male participants across 31 provinces in China. All adolescents (10-19 years old), early adolescents (10-14), and late adolescents (15-19) were chosen as exposure windows. Heat waves were defined as periods lasting 2‒4 consecutive days with the daily temperature exceeding the 75th, 90th, and 92.5th percentiles. We employed multivariate logistic regression models to assess the associations between exposure to heat waves during adolescence and APOs.
The results revealed significant associations between male exposure to heat wave events during late adolescence and spontaneous abortion (P < 0.05), which was more pronounced in South China. In contrast, no statistically significant associations were detected between males' exposure to heat wave events during adolescence and their partners' preterm birth (P > 0.05 for all comparisons). The exposure of females to heat waves during adolescence was not significantly associated with subsequent spontaneous abortion or preterm birth (P > 0.05 for all comparisons).
This study demonstrates that spontaneous abortion in females is associated with heat wave exposure in their male partner during adolescence.
暴露于热浪中会对人类健康产生重大影响。然而，关于青春期暴露于热浪对不良妊娠结局（APO）的长期影响的研究却很少。本研究旨在探讨青春期暴露于热浪的长期影响与不良妊娠结局之间的关系。
我们分析了来自中国31个省份的3376名女性和3013名男性参与者的数据。所有青少年（10 - 19岁）、早期青少年（10 - 14岁）和晚期青少年（15 - 19岁）被选为暴露窗口。热浪被定义为连续2至4天，每日气温超过第75、90和92.5百分位数的时期。我们采用多变量逻辑回归模型来评估青春期暴露于热浪与不良妊娠结局之间的关联。
结果显示，男性在青春期后期暴露于热浪事件与自然流产之间存在显著关联（P < 0.05），在中国南方更为明显。相比之下，男性在青春期暴露于热浪事件与其伴侣早产之间未检测到统计学上的显著关联（所有比较P > 0.05）。女性在青春期暴露于热浪与随后的自然流产或早产之间无显著关联（所有比较P > 0.05）。
本研究表明，女性自然流产与其男性伴侣在青春期暴露于热浪有关。
