Kim B S, Hui K M
J Immunol. 1985 Jul;135(1):255-60.
Serial transfer of spleen cells immune to allogeneic or semi-allogeneic cells induced transferable splenomegaly and general immune deficiencies, including the lack of proliferative responses to T and B cell mitogens and antibody responses to specific antigens. Parallel experiments with spleen cells from mice that had been administered rectally with allogeneic spleen or sperm cells also resulted in a similar immunodeficiency. The immune deficiencies were transferable into normal mice by injection of spleen cells, cellfree extracts, or culture supernatants of spleen cells from immunodeficient mice. The particle responsible for transmission of immunodeficiency appears to be a high m.w. (greater than 2 X 10(6], 1.14 g/ml density agent. These results suggest strongly that serial transfer of lymphocytes immune to alloantigens triggers the release of a transmissible virus-like agent, which results in an immunodeficiency similar to acquired immune deficiency syndrome (AIDS) of humans. Therefore, this system may provide a valuable animal model system for studying AIDS.
对同种异体或半同种异体细胞免疫的脾细胞进行连续转移，可诱发可转移的脾肿大和全身性免疫缺陷，包括对T和B细胞有丝分裂原的增殖反应缺乏以及对特定抗原的抗体反应缺乏。对经直肠给予同种异体脾细胞或精子细胞的小鼠的脾细胞进行的平行实验也导致了类似的免疫缺陷。通过注射来自免疫缺陷小鼠的脾细胞、无细胞提取物或脾细胞培养上清液，可将免疫缺陷转移到正常小鼠体内。负责免疫缺陷传播的颗粒似乎是一种高分子量（大于2×10⁶，密度为1.14 g/ml）的因子。这些结果有力地表明，对同种异体抗原免疫的淋巴细胞的连续转移会触发一种可传播的病毒样因子的释放，这导致了一种类似于人类获得性免疫缺陷综合征（AIDS）的免疫缺陷。因此，该系统可能为研究艾滋病提供一个有价值的动物模型系统。
