Pastier Clément, Ben Hmida Wafa, Lefèvre Jérémie H, Denost Quentin, Schwarz Lilian, Berdah Stéphane, Cotte Eddy, Karoui Mehdi, Maggiori Léon, Abdalla Solafah, Brouquet Antoine, Benoist Stéphane
Department of Oncologic and Digestive Surgery, Bicêtre Hospital, Assistance Publique- Hôpitaux de Paris, Le Kremlin-Bicêtre, France.
Department of Colorectal Surgery, Saint-Antoine Hospital, Assistance Publique Hôpitaux de Paris, Paris, France.
World J Surg. 2025 Jul;49(7):1747-1756. doi: 10.1002/wjs.12634. Epub 2025 May 21.
Anastomotic leakage (AL) impacts short-term and long-term outcomes after colorectal surgery, yet no consensus exists regarding its diagnosis and management. The aim was to establish a proactive consensus-based approach for diagnosing and treating AL following rectal cancer surgery through a national survey.
A questionnaire was designed to assess 24 clinical scenarios related to the diagnosis and management of fistulas in low colorectal (LCA) or coloanal anastomosis (CAA) with a diverting ileostomy.
A total of 203 surgeons from three surgical societies participated. Consensus was reached on four key indicators warranting further investigation of AL: CRP > 250 mg/L, fever ≥ 38.5°C, tachycardia > 100 bpm, and diffuse abdominal pain. In the presence of any warning sign, 87% recommended an urgent contrast-enhanced abdominopelvic CT scan without routine rectal contrast as the first-line diagnostic tool. Isolated extra-digestive air bubbles or uncollected effusions without air bubbles were managed with antibiotics (61%-78%). A perianastomotic collection required an anal examination under general anesthesia (70%). For treatment, transanal drainage (56%) was preferred over image-guided percutaneous drainage, combined with endoluminal vacuum therapy and at least 7 days of antibiotics (97%). Drain removal was recommended (64%) when imaging confirmed the absence of residual collection.
This national survey established a consensus-driven proactive management algorithm for LCA/CAA fistulas. Further validation controlled trial is needed to confirm the effectiveness in reducing AL-related complications.
吻合口漏(AL)会影响结直肠手术后的短期和长期预后,但在其诊断和管理方面尚无共识。本研究旨在通过全国性调查,建立一种基于共识的主动方法来诊断和治疗直肠癌手术后的AL。
设计了一份问卷,以评估24种与低位结直肠(LCA)或结肠肛管吻合术(CAA)并带有转流性回肠造口术的瘘管诊断和管理相关的临床情况。
来自三个外科学会的203名外科医生参与了研究。就需要进一步调查AL的四个关键指标达成了共识:CRP>250mg/L、发热≥38.5°C、心动过速>100次/分钟和弥漫性腹痛。出现任何警示信号时,87%的人建议进行紧急的腹部盆腔增强CT扫描,不进行常规直肠造影,作为一线诊断工具。孤立的消化道外气泡或无气泡的未收集积液采用抗生素治疗(61%-78%)。吻合口周围积液需要在全身麻醉下进行肛门检查(70%)。在治疗方面,经肛门引流(56%)比影像引导下经皮引流更受青睐,同时结合腔内负压治疗和至少7天的抗生素治疗(97%)。当影像学证实无残留积液时,建议拔除引流管(64%)。
这项全国性调查建立了一种基于共识的主动管理算法,用于LCA/CAA瘘管。需要进一步的验证性对照试验来证实其在减少AL相关并发症方面的有效性。