Landry F, Bouchard C, Dumesnil J
JAMA. 1985 Jul 5;254(1):77-80.
We studied the sensitivity of cardiac structures to endurance training. To evaluate variability in adaptation, 20 sedentary subjects and ten pairs of monozygotic twins were submitted to a 20-week endurance training program. Maximal oxygen uptake increased significantly in both groups: 11 mL O2/kg/min-1 or 30% in the sedentary group and 6 mL O2/kg/min-1 or 13% in the monozygotic twins. Statistically significant increases in left ventricular diameter, posterior wall and septal thicknesses, as well as left ventricular end-diastolic volume and left ventricular mass were observed in the sedentary subjects, but not in the monozygotic twins. We could demonstrate that after training, twin pairs differed more from each other than at the start. Concomitantly, within-pair resemblance was greater after training than before. Results indicate that cardiac dimensions are amenable to significant modifications under controlled endurance training conditions and furthermore that the extent and variability of the response of cardiac structures to training are perhaps genotype dependent.
我们研究了心脏结构对耐力训练的敏感性。为了评估适应性的变异性，20名久坐不动的受试者和十对同卵双胞胎参加了一项为期20周的耐力训练计划。两组的最大摄氧量均显著增加：久坐不动组增加了11 mL O2/kg/min-1或30%，同卵双胞胎组增加了6 mL O2/kg/min-1或13%。在久坐不动的受试者中观察到左心室直径、后壁和室间隔厚度以及左心室舒张末期容积和左心室质量有统计学意义的增加，但在同卵双胞胎中未观察到。我们可以证明，训练后，双胞胎对彼此之间的差异比开始时更大。同时，训练后双胞胎对内部的相似性比训练前更大。结果表明，在受控的耐力训练条件下，心脏尺寸易于发生显著变化，此外，心脏结构对训练的反应程度和变异性可能取决于基因型。
