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早年持续性中耳疾病的后果。腭裂患儿的耳科、听力学及发育方面的表现。

Consequences of unremitting middle-ear disease in early life. Otologic, audiologic, and developmental findings in children with cleft palate.

作者信息

Hubbard T W, Paradise J L, McWilliams B J, Elster B A, Taylor F H

出版信息

N Engl J Med. 1985 Jun 13;312(24):1529-34. doi: 10.1056/NEJM198506133122401.

Abstract

To learn whether chronic otitis media with effusion during early life has lasting otologic, audiologic, or developmental consequences, we evaluated 24 closely matched pairs of children with repaired palatal clefts whose treatment had been equivalent except with regard to persistent otitis media during early life. One group had undergone early (mean age, 3.0 months) myringotomy with placement of tympanostomy tubes, followed by assiduous monitoring and an aggressive treatment program to maintain ventilation in the middle ear. The other group had undergone initial myringotomy later (mean age, 30.8 months) or not at all (two subjects) and presumably had had continuous middle-ear effusion throughout most or all of the first few years of life. Eardrum scarring was equal in both groups. Hearing acuity and consonant articulation were impaired in both groups, but hearing acuity was less impaired (P = 0.05 to 0.10) and consonant articulation significantly less impaired (P = 0.03) in the group undergoing early myringotomy. Mean verbal, performance, and full-scale IQs and scores on psychosocial indexes were normal in both groups and did not differ significantly between the groups. These findings support the hypothesis that early, longstanding otitis media may result in impairment of hearing and of speech, but they do not support the hypothesis that cognitive, language, and psychosocial development are adversely affected.

摘要

为了解婴幼儿期慢性分泌性中耳炎是否会产生持久的耳科、听力学或发育方面的后果,我们评估了24对腭裂修复患儿,这些患儿除了在婴幼儿期是否患有持续性中耳炎外,其他治疗情况均相同。一组患儿早期(平均年龄3.0个月)接受了鼓膜切开术并置入鼓膜造孔管,随后进行了仔细监测和积极的治疗方案以维持中耳通气。另一组患儿鼓膜切开术时间较晚(平均年龄30.8个月)或根本未接受该手术(两名患儿),推测在生命的最初几年大部分或全部时间中耳都有积液。两组患儿的鼓膜瘢痕形成情况相同。两组患儿的听力敏锐度和辅音清晰度均受损,但早期接受鼓膜切开术的患儿听力敏锐度受损程度较轻(P = 0.05至0.10),辅音清晰度受损程度明显较轻(P = 0.03)。两组患儿的平均语言、操作和全量表智商以及心理社会指标得分均正常,且两组间无显著差异。这些发现支持早期长期中耳炎可能导致听力和言语受损的假说,但不支持认知、语言和心理社会发育会受到不利影响的假说。

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