Kania B F
Res Vet Sci. 1985 Mar;38(2):179-83.
The immobilising action of Immobyl (fentanyl : azaperone, 5:1) in six sheep has been analysed on the basis of the changes in dopamine, noradrenalin, adrenalin, homovanillic acid and 5-hydroxytryptamine concentrations in the corpus striatum, frontal motor cortex, pons, cerebellum and lumbosacral spinal cord as compared to the control animals which were given saline. Forty minutes after intramuscular injection of an immobilising dose (0.19 mg [kg bodyweight]-1), Immobyl caused a significant decrease in dopamine, noradrenalin and 5-hydroxytryptamine concentrations and a similarly large decrease in homovanillic acid concentration (47 per cent) in the corpus striatum with a simultaneous but insignificant increase in the concentrations of these substances in the frontal motor cortex region. In Immobyl immobilisation, sheep showed a significant increase in dopamine concentration with an equally significant decrease in homovanillic acid concentrations in the lumbosacral part of the spinal cord. It is suggested that fentanyl stimulates the presynaptic dopamine receptors in the corpus striatum in sheep, significantly decreasing synthesis and release of dopamine and noradrenalin and intensifying an inhibitory effect of the corpus striatum on locomotor activity and thus causes the immobilisation of the animal.
已根据纹状体、额叶运动皮层、脑桥、小脑和腰骶脊髓中多巴胺、去甲肾上腺素、肾上腺素、高香草酸和5-羟色胺浓度的变化，分析了Immobyl（芬太尼：阿扎哌隆，5:1）对六只绵羊的制动作用，将其与注射生理盐水的对照动物进行比较。肌肉注射制动剂量（0.19 mg [kg体重]-1）40分钟后，Immobyl导致纹状体中多巴胺、去甲肾上腺素和5-羟色胺浓度显著降低，高香草酸浓度同样大幅下降（47%），同时额叶运动皮层区域这些物质的浓度虽有增加但不显著。在Immobyl制动过程中，绵羊脊髓腰骶部的多巴胺浓度显著增加，高香草酸浓度同样显著降低。提示芬太尼刺激绵羊纹状体中的突触前多巴胺受体，显著减少多巴胺和去甲肾上腺素的合成与释放，增强纹状体对运动活动的抑制作用，从而导致动物制动。
