Cheng Yu, Wu Shouling, Chen Shuohua, Wu Yuntao
School of Public Health, North China University of Science and Technology, Tangshan, 063210, China.
Kailuan General Hospital, Tangshan, 063000, China.
Sci Rep. 2025 May 21;15(1):17687. doi: 10.1038/s41598-025-02342-y.
Previous studies have mainly explored the effects of body mass index (BMI) and triglyceride-glucose index (TyG index) on cardiovascular disease (CVD) separately or by examining the composite parameter (TyG-BMI) formed by multiplying the two and its association with CVD. However, few studies have investigated the combined effect of BMI categories and the TyG index on CVD. This study aimed to determine the association of BMI categories combined with the TyG index in new-onset CVD. A total of 94,002 participants were included from the Kailuan study. Their BMI combined with the TyG index was categorized into six groups: Low-BMI/Low-TyG, Middle-BMI/Low-TyG, High-BMI/Low-TyG, Low-BMI/High-TyG, Middle-BMI/High-TyG, and High-BMI/High-TyG. A multifactorial Cox proportional hazards model was used to analyze the longitudinal association between BMI combined with the TyG index and new-onset CVD events. During a follow-up period of 15.95 ± 3.59 years, 9791 new CVD events were recorded. After adjusting for confounding factors such as sex, age, smoking, drinking, physical activity, systolic blood pressure, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid, high-sensitivity C-reactive protein, antihypertensive drugs, hypoglycemic drugs, and lipid-lowering drugs, Cox regression analysis showed that the risk of CVD events was 52% higher in the High-BMI/High-TyG group (HR: 1.52; 95% CI 1.42-1.64) compared to the Low-BMI/Low-TyG group. The combination of high BMI (≥ 28.0) and high TyG index (> 8.58) significantly increases individual CVD risk. This study suggests that the combination of BMI and the TyG index may better help identify individuals at risk of developing CVD.
以往的研究主要分别探讨了体重指数（BMI）和甘油三酯-葡萄糖指数（TyG指数）对心血管疾病（CVD）的影响，或者通过考察将二者相乘得到的复合参数（TyG-BMI）及其与CVD的关联来进行研究。然而，很少有研究调查BMI类别和TyG指数对CVD的联合作用。本研究旨在确定BMI类别与TyG指数相结合在新发CVD中的关联。共纳入了开滦研究中的94,002名参与者。他们的BMI与TyG指数相结合被分为六组：低BMI/低TyG、中BMI/低TyG、高BMI/低TyG、低BMI/高TyG、中BMI/高TyG和高BMI/高TyG。采用多因素Cox比例风险模型分析BMI与TyG指数相结合和新发CVD事件之间的纵向关联。在15.95±3.59年的随访期内，记录了9791例新发CVD事件。在调整了性别、年龄、吸烟、饮酒、体力活动、收缩压、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、尿酸、高敏C反应蛋白、抗高血压药物、降糖药物和降脂药物等混杂因素后，Cox回归分析显示，与低BMI/低TyG组相比，高BMI/高TyG组发生CVD事件的风险高52%（HR：1.52；95%CI 1.42-1.64）。高BMI（≥28.0）和高TyG指数（>8.58）的组合显著增加个体患CVD的风险。本研究表明，BMI与TyG指数的组合可能更有助于识别有发生CVD风险的个体。
