Benrubi G I, Norvell M, Nuss R C, Robinson H
Gynecol Oncol. 1985 Jul;21(3):306-13. doi: 10.1016/0090-8258(85)90268-9.
cis-Platinum is a chemotherapeutic agent with benefits often limited by the severe gastrointestinal reactions it produces in nearly all patients. Persistent anorexia, nausea, and vomiting may continue for days after therapy and are poorly controlled by conventional antiemetics. Patients at times refuse continuation of cis-platinum chemotherapy because of these severe gastrointestinal side effects. Intravenous methylprednisolone (Solu-medrol) as well as intravenous metoclopramide (Reglan) have been shown effective in the treatment of chemotherapy-induced nausea and vomiting. This randomized, double-blind study is a comparison of the efficacy of Solu-medrol vs Reglan, as well as, the combination of Solu-medrol and Reglan in the prevention of cis-platinum-induced nausea and vomiting. In this study patients receiving Reglan had better protection from vomiting than patients receiving Solu-medrol (P = 0.0564). Patients receiving the combination of Reglan and Solu-medrol had better protection from vomiting than patients receiving Reglan alone (P = 0.0332), or patients receiving Solu-medrol alone (P = 0.0010). Finally, older patients experienced less vomiting than younger patients, regardless of the anti-emetic drugs used (P = 0.0730).
顺铂是一种化疗药物，其益处往往受到几乎所有患者都会出现的严重胃肠道反应的限制。持续性厌食、恶心和呕吐在治疗后可能会持续数天，且常规止吐药对其控制效果不佳。患者有时会因这些严重的胃肠道副作用而拒绝继续接受顺铂化疗。静脉注射甲泼尼龙（甲强龙）以及静脉注射甲氧氯普胺（胃复安）已被证明对治疗化疗引起的恶心和呕吐有效。这项随机双盲研究比较了甲强龙与胃复安以及甲强龙和胃复安联合使用在预防顺铂引起的恶心和呕吐方面的疗效。在这项研究中，接受胃复安的患者比接受甲强龙的患者对呕吐有更好的防护作用（P = 0.0564）。接受胃复安和甲强龙联合治疗的患者比单独接受胃复安治疗的患者（P = 0.0332）或单独接受甲强龙治疗的患者（P = 0.0010）对呕吐有更好的防护作用。最后，无论使用何种止吐药物，老年患者的呕吐情况都比年轻患者少（P = 0.0730）。
