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Enhancing RNA vaccine safety through localized delivery strategies.

作者信息

Kimura Taishi

机构信息

HDT Bio, Seattle, WA, USA.

出版信息

Vaccine Insights. 2025 Mar;4(2):41-45. Epub 2025 Mar 20.

PMID:40400697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12094610/
Abstract
摘要

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mRNA vaccines for infectious diseases - advances, challenges and opportunities.传染病的 mRNA 疫苗：进展、挑战与机遇。
Nat Rev Drug Discov. 2024 Nov;23(11):838-861. doi: 10.1038/s41573-024-01042-y. Epub 2024 Oct 4.
2
Complete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency.自我扩增RNA中经修饰核苷酸的完全取代可抑制干扰素反应并提高效力。
Nat Biotechnol. 2025 May;43(5):720-726. doi: 10.1038/s41587-024-02306-z. Epub 2024 Jul 8.
3
Safety outcomes following COVID-19 vaccination and infection in 5.1 million children in England.英格兰 510 万儿童接种 COVID-19 疫苗和感染后的安全结果。
Nat Commun. 2024 May 27;15(1):3822. doi: 10.1038/s41467-024-47745-z.
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An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial.一种针对奥密克戎的、自我扩增的 COVID-19 mRNA 加强疫苗：一项 2/3 期随机试验。
Nat Med. 2024 May;30(5):1363-1372. doi: 10.1038/s41591-024-02955-2. Epub 2024 Apr 18.
5
Overview of U.S. COVID-19 vaccine safety surveillance systems.美国 COVID-19 疫苗安全监测系统概述。
Vaccine. 2024 Sep 17;42 Suppl 3:125748. doi: 10.1016/j.vaccine.2024.02.065. Epub 2024 Apr 16.
6
Safety and immunogenicity of VLPCOV-02, a SARS-CoV-2 self-amplifying RNA vaccine with a modified base, 5-methylcytosine.VLPCOV-02的安全性和免疫原性，一种带有修饰碱基5-甲基胞嘧啶的新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）自我扩增RNA疫苗。
iScience. 2024 Jan 22;27(2):108964. doi: 10.1016/j.isci.2024.108964. eCollection 2024 Feb 16.
7
Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects.组合设计可离子化脂质纳米粒用于肌肉选择性 mRNA 递送，最大限度减少脱靶效应。
Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2309472120. doi: 10.1073/pnas.2309472120. Epub 2023 Dec 7.
8
A localizing nanocarrier formulation enables multi-target immune responses to multivalent replicating RNA with limited systemic inflammation.一种定位纳米载体配方可使多价复制 RNA 引发多靶免疫反应，并将全身性炎症控制在有限范围内。
Mol Ther. 2023 Aug 2;31(8):2360-2375. doi: 10.1016/j.ymthe.2023.06.017. Epub 2023 Jul 3.
9
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine-associated myocarditis.SARS-CoV-2 mRNA 疫苗相关心肌炎中的细胞因子病伴异常细胞毒性淋巴细胞和促纤维化髓系反应。
Sci Immunol. 2023 May 12;8(83):eadh3455. doi: 10.1126/sciimmunol.adh3455. Epub 2023 May 5.
10
A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine.一项关于自我扩增型新冠病毒mRNA疫苗的I/II期随机、双盲、安慰剂对照试验。
NPJ Vaccines. 2022 Dec 13;7(1):161. doi: 10.1038/s41541-022-00590-x.