Becker Hannah, Khoshaba Edena R, Ansell David A
Medical School, Rush University Medical Center, Chicago, USA.
Internal Medicine, Rush University Medical Center, Chicago, USA.
Cureus. 2025 Apr 21;17(4):e82731. doi: 10.7759/cureus.82731. eCollection 2025 Apr.
Guillain-Barré Syndrome (GBS) is a rare, immune-mediated polyneuropathy that typically presents with ascending weakness, areflexia, and sensory disturbances. This case highlights an atypical presentation of GBS in an 18-year-old female, whose initial symptoms included primarily sensory deficits following routine exercise. The diagnostic process was complicated by unremarkable initial laboratory and imaging findings, but cerebrospinal fluid analysis revealed albuminocytologic dissociation, and electromyography confirmed acute demyelinating polyneuropathy. This case underscores the diagnostic challenges posed by atypical variants of GBS, the importance of thorough neurological evaluation, and the critical role of timely intervention in optimizing outcomes.
格林-巴利综合征(GBS)是一种罕见的、免疫介导的多发性神经病,通常表现为进行性肌无力、腱反射消失和感觉障碍。本病例突出了一名18岁女性GBS的非典型表现,其初始症状主要为常规运动后的感觉缺陷。诊断过程因最初实验室和影像学检查结果无异常而变得复杂,但脑脊液分析显示蛋白细胞分离,肌电图证实为急性脱髓鞘性多发性神经病。本病例强调了GBS非典型变异型带来的诊断挑战、全面神经评估的重要性以及及时干预对优化预后的关键作用。