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本文引用的文献

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Diagnosis, Treatment and Long-Term Management of Vitamin B12 Deficiency in Adults: A Delphi Expert Consensus.成人维生素B12缺乏症的诊断、治疗及长期管理：德尔菲专家共识
J Clin Med. 2024 Apr 10;13(8):2176. doi: 10.3390/jcm13082176.
2
Pernicious Anemia: The Hematological Presentation of a Multifaceted Disorder Caused by Cobalamin Deficiency.巨幼细胞贫血：由钴胺素缺乏引起的多方面疾病的血液学表现。
Nutrients. 2022 Apr 17;14(8):1672. doi: 10.3390/nu14081672.
3
Autoimmune Hemolytic Anemias.自身免疫性溶血性贫血
N Engl J Med. 2021 Oct 7;385(15):1407-1419. doi: 10.1056/NEJMra2033982.
4
AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis: Expert Review.美国胃肠病学会关于萎缩性胃炎诊断与管理的临床实践更新：专家综述
Gastroenterology. 2021 Oct;161(4):1325-1332.e7. doi: 10.1053/j.gastro.2021.06.078. Epub 2021 Aug 26.
5
Autoimmune polyglandular syndrome type III associated with antineutrophil cytoplasmic autoantibody-mediated crescentic glomerulonephritis: A case report and literature review.与抗中性粒细胞胞浆自身抗体介导的新月体性肾小球肾炎相关的Ⅲ型自身免疫性多腺体综合征：病例报告及文献复习
Medicine (Baltimore). 2020 Feb;99(7):e19179. doi: 10.1097/MD.0000000000019179.
6
Vitamin B12 deficiency.维生素B12缺乏症
BMJ. 2014 Sep 4;349:g5226. doi: 10.1136/bmj.g5226.
7
Clinical practice. Vitamin B12 deficiency.临床实践。维生素B12缺乏症。
N Engl J Med. 2013 Jan 10;368(2):149-60. doi: 10.1056/NEJMcp1113996.
8
Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency: three case reports and review of the literature.钴胺素缺乏导致的溶血和高同型半胱氨酸血症：三例病例报告并文献复习。
J Hematol Oncol. 2008 Dec 18;1:26. doi: 10.1186/1756-8722-1-26.
9
Nutritional neuropathies.营养性神经病
Neurol Clin. 2007 Feb;25(1):209-55. doi: 10.1016/j.ncl.2006.11.001.
10
Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency.钴胺素缺乏症的当前血液学表现。对201例有记录的钴胺素缺乏症患者的研究。
Clin Lab Haematol. 2006 Feb;28(1):50-6. doi: 10.1111/j.1365-2257.2006.00755.x.

伴有严重溶血性贫血的恶性贫血

Pernicious Anemia Presenting With Severe Hemolytic Anemia.

作者信息

Chung Jeffrey

机构信息

Internal Medicine, University of California, Los Angeles (UCLA) Ronald Reagan Medical Center, Los Angeles, USA.

出版信息

Cureus. 2025 Apr 21;17(4):e82739. doi: 10.7759/cureus.82739. eCollection 2025 Apr.

DOI:10.7759/cureus.82739
PMID:40400815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12094849/
Abstract

Pernicious anemia is an autoimmune disease characterized by vitamin B12 deficiency due to antibodies that target intrinsic factor and/or parietal cells in the stomach. Hemolytic anemia is rarely seen in vitamin B12 deficiency. This case report highlights a patient with a history of autoimmune thyroid disease who presented with severe hemolytic anemia and vitamin B12 deficiency from pernicious anemia. This report discusses the association of hemolytic anemia with vitamin B12 deficiency, the association of pernicious anemia with other autoimmune diseases, and the treatment of pernicious anemia.

摘要

恶性贫血是一种自身免疫性疾病，其特征是由于针对胃内的内因子和/或壁细胞的抗体导致维生素B12缺乏。溶血性贫血在维生素B12缺乏症中很少见。本病例报告重点介绍了一名有自身免疫性甲状腺疾病史的患者，该患者出现了严重的溶血性贫血和由恶性贫血导致的维生素B12缺乏。本报告讨论了溶血性贫血与维生素B12缺乏的关联、恶性贫血与其他自身免疫性疾病的关联以及恶性贫血的治疗。