Khadka Sujita, Sankhi Sabina, Marasine Nirmal Raj
Department of Pharmacy, CiST College, New Baneshwor, Kathmandu, Nepal.
Department of Pharmacy, Shree College of Technology, Chitwan, Nepal.
Hosp Pharm. 2025 May 18:00185787251337594. doi: 10.1177/00185787251337594.
Pharmacists with their unique roles and responsibilities, play a vital role in improving patients knowledge and medication adherence, ultimately contributing to improved health-related quality of life (HRQoL). This study aims to evaluate the impact of pharmacist-led educational intervention on disease knowledge, medication adherence, and HRQoL among patients with rheumatoid arthritis (RA). A randomized, single-blind, parallel, controlled study was conducted among 118 patients with RA visiting the outpatient department of the National Center for Rheumatic Diseases, Kathmandu, Nepal. Data on disease knowledge, medication adherence, and HRQoL were collected at baseline and follow-up at 12 weeks. Rheumatoid Arthritis Knowledge Assessment Scale (RAKAS), General Medication Adherence Scale (GMAS), and European Quality of Life Scale (EuroQol) 5-Dimension 5-Level (EQ-5D-5L) were used to measure knowledge level, adherence level, and HRQoL, respectively. At follow-up, disease knowledge significantly improved in the intervention group (IG) (excellent knowledge: 42;71.2% vs 9;15.3% at baseline), while the change was minimal in control group (CG) (12;20.3% vs 22.0% at baseline). Similarly, the IG showed a marked increase in medication adherence (high: 57;96.6% vs 20;33.9% at baseline), with only slight improvement in CG (37;62.7% vs 29;49.2% at baseline). The Proportion of patients with the best HRQoL significantly increased in the IG (48;81.4% vs 17;28.8% at baseline), while it remained unchanged in CG. Statistically significant improvements were observed in disease knowledge, medication adherence and HRQoL scores ( < .01) in the IG. The intervention group demonstrated significantly improved disease knowledge, medication adherence, and HRQoL scores, while control group showed minimal changes, highlighting the effectiveness of pharmacist-led educational intervention in disease management.
药剂师凭借其独特的角色和职责，在提高患者知识水平和药物依从性方面发挥着至关重要的作用，最终有助于改善健康相关生活质量（HRQoL）。本研究旨在评估药剂师主导的教育干预对类风湿性关节炎（RA）患者的疾病知识、药物依从性和HRQoL的影响。在尼泊尔加德满都国家风湿病中心门诊部就诊的118例RA患者中进行了一项随机、单盲、平行对照研究。在基线和12周随访时收集疾病知识、药物依从性和HRQoL的数据。类风湿性关节炎知识评估量表（RAKAS）、一般药物依从性量表（GMAS）和欧洲生活质量量表（EuroQol）5维度5等级（EQ-5D-5L）分别用于测量知识水平、依从水平和HRQoL。在随访时，干预组（IG）的疾病知识显著改善（优秀知识：42例；71.2%，而基线时为9例；15.3%），而对照组（CG）的变化最小（12例；20.3%，而基线时为22.0%）。同样，IG组的药物依从性显著提高（高：57例；96.6%，而基线时为20例；33.9%），CG组仅有轻微改善（37例；62.7%，而基线时为29例；49.2%）。IG组中HRQoL最佳的患者比例显著增加（48例；81.4%，而基线时为17例；28.8%），而CG组保持不变。IG组在疾病知识、药物依从性和HRQoL评分方面观察到具有统计学意义的改善（P<0.01）。干预组的疾病知识、药物依从性和HRQoL评分显著改善，而对照组变化最小，突出了药剂师主导的教育干预在疾病管理中的有效性。
