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新生儿治疗性低温：文献计量分析与可视化研究

Therapeutic hypothermia for neonates: a bibliometric analysis and visualization research.

作者信息

Zhou Tingting, Liang Peishan, Dai Na, Ma Mingxin, Lin Jiangang, Zhu Jie, Ren Guangli

机构信息

Department of Pediatric, General Hospital of Southern Theater Command of PLA, Guangzhou, China.

Graduate School, Guangzhou University of Chinese Medicine, Guangzhou, China.

出版信息

Front Neurol. 2025 May 7;16:1565749. doi: 10.3389/fneur.2025.1565749. eCollection 2025.

DOI:10.3389/fneur.2025.1565749
PMID:40401026
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12092385/
Abstract

BACKGROUND

Therapeutic hypothermia is an important treatment for cerebral protection and has a positive effect on neonatal encephalopathy. This study aims to analyze the research hotspots and frontiers of therapeutic hypothermia for neonates through bibliometric analysis and visualization research.

METHODS

The articles and reviews on therapeutic hypothermia for neonates were identified from the Web of Science Core Collection (WOSCC) database on October 18, 2024. CiteSpace and VOSviewer were used to analyze the countries/regions, institutions, authors, journals, references, and author keywords.

RESULTS

A total of 1,199 articles were retrieved from 378 institutions in 75 countries/regions. The annual number of publications and citations showed an upward trend in this field. Massaro, An N. N., and Shankaran. S. were the key authors who had most publications and citations. was the most popular journal in the field, was the most influential. All the author keywords were divided into 12 clusters, and "hypoxia-ischemia encephalopathy," "therapeutic hypothermia" and "perinatal asphyxia" were high-frequency keywords in this field. Keyword burst shows that "childhood outcome," "neonatal seizure," "preterm," and "risk factors" were important aspects of research in recent years.

CONCLUSION

The present study is the first to apply bibliometric analysis to explore therapeutic hypothermia for neonates, aiming to identify research hotspots and frontiers in this field. In recent years, research on therapeutic hypothermia for neonates has rapidly increased, with therapeutic hypothermia for perinatal asphyxia neonates being a research hotspot. To improve the neurological prognosis of neonates, more researches focused on how to expand the benefits of the neonatal population and enhance neuroprotective effects. It may provide future research directions for neonatal experts.

摘要

背景

治疗性低温是一种重要的脑保护治疗方法，对新生儿脑病有积极作用。本研究旨在通过文献计量分析和可视化研究，分析新生儿治疗性低温的研究热点和前沿。

方法

于2024年10月18日从Web of Science核心合集（WOSCC）数据库中检索关于新生儿治疗性低温的文章和综述。使用CiteSpace和VOSviewer分析国家/地区、机构、作者、期刊、参考文献和作者关键词。

结果

共检索到来自75个国家/地区378个机构的1199篇文章。该领域的年出版物数量和被引频次呈上升趋势。马萨罗、安·N·N.以及尚卡兰·S.是发表文章和被引频次最多的关键作者。 是该领域最受欢迎的期刊， 是最具影响力的。所有作者关键词分为12个聚类，“缺氧缺血性脑病”“治疗性低温”和“围产期窒息”是该领域的高频关键词。关键词突现显示“儿童期结局”“新生儿惊厥”“早产”和“危险因素”是近年来研究的重要方面。

结论

本研究首次应用文献计量分析探索新生儿治疗性低温，旨在识别该领域的研究热点和前沿。近年来，新生儿治疗性低温的研究迅速增加，围产期窒息新生儿的治疗性低温是一个研究热点。为改善新生儿的神经预后，更多研究聚焦于如何扩大新生儿群体的受益范围并增强神经保护作用。这可能为新生儿专家提供未来的研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707a/12092385/393ad6a4d371/fneur-16-1565749-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707a/12092385/22e44eca858a/fneur-16-1565749-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707a/12092385/3e3a20ea0d0f/fneur-16-1565749-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707a/12092385/9acc64e6cb1d/fneur-16-1565749-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707a/12092385/d35bce6f0514/fneur-16-1565749-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/707a/12092385/393ad6a4d371/fneur-16-1565749-g010.jpg

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Therapeutic hypothermia in preterm infants under 36 weeks: Case series on outcomes and brain MRI findings.36周以下早产儿的治疗性低温：关于结局和脑部MRI结果的病例系列
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Esophageal Versus Rectal Temperature Monitoring During Whole-Body Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy: Association with Short- and Long-Term Outcomes.食管与直肠温度监测在全身低温治疗缺氧缺血性脑病中的应用：与短期和长期结局的关系。
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Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome - a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III).
ALBINO 研究的详细统计分析计划：别嘌呤醇联合亚低温治疗缺氧缺血性脑损伤对神经认知结局的影响 - 一项针对优效性的盲法随机安慰剂对照平行分组多中心临床试验（III 期）。
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An observational, multicenter, registry-based cohort study of Turkish Neonatal Society in neonates with Hypoxic ischemic encephalopathy.一项基于观察性、多中心、注册的土耳其新生儿学会队列研究，纳入了患有缺氧缺血性脑病的新生儿。
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Remote Monitoring for Seizures During Therapeutic Hypothermia in Neonates With Hypoxic-Ischemic Encephalopathy.远程监测新生儿缺氧缺血性脑病亚低温治疗期间的癫痫发作。
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