Hiasa Y, Konishi N, Kitahori Y, Shimoyama T
Food Chem Toxicol. 1985 Jun;23(6):619-23. doi: 10.1016/0278-6915(85)90189-9.
Sodium oleate was added to the drinking-water of groups of 50 male and 50 female F344 rats at levels of 2.5 and 5.0% for 108 wk. The mean liver weight in males given 5% oleate was lower than that of the males given 2.5% oleate or distilled water alone. The mean thymus weight of females given 5% oleate was higher than that of females given 2.5% oleate or distilled water. There were no statistically significant differences between treated and control rats in the results of the urine and serum analyses or haematological determinations or in the incidence of tumours, apart from pancreatic tumours. The latter, in the males, showed some increase over the concurrent controls but did not differ significantly from the reported spontaneous incidence in this strain. It was concluded that sodium oleate does not induce tumours when given orally to F344 rats.
将油酸钠以2.5%和5.0%的浓度添加到每组50只雄性和50只雌性F344大鼠的饮用水中，持续108周。给予5%油酸钠的雄性大鼠的平均肝脏重量低于给予2.5%油酸钠或仅给予蒸馏水的雄性大鼠。给予5%油酸钠的雌性大鼠的平均胸腺重量高于给予2.5%油酸钠或蒸馏水的雌性大鼠。除胰腺肿瘤外，处理组和对照组大鼠在尿液和血清分析结果、血液学测定或肿瘤发生率方面均无统计学显著差异。雄性大鼠的胰腺肿瘤与同期对照组相比有所增加，但与该品系报告的自发发生率无显著差异。得出的结论是，给F344大鼠口服油酸钠不会诱发肿瘤。
