Clair P, Claustrat B, Jordan D, Dechaud H, Sassolas G
Horm Res. 1985;21(4):220-3. doi: 10.1159/000180052.
In this study the daily variations of plasma sex hormone-binding globulin (SHBG) binding capacity were measured together with plasma testosterone and luteinizing hormone (LH) concentrations in 7 healthy rested adult males. Plasma SHBG-binding capacity demonstrated a significant circadian rhythm (acrophase = 2.06 p.m.; mesor = 0.35 +/- 0.6 ng testosterone bound/100 ml; amplitude = 17% of the mesor). Plasma testosterone also showed a circadian rhythm (acrophase = 7.02 a.m.; mesor = 4.38 +/- 0.67 ng/ml; amplitude = 18% of the mesor). The free testosterone index (or the ratio between plasma testosterone and SHBG-binding capacity) was not correlated with plasma LH levels. In our hands this last parameter did not vary according to a circadian pattern. These data are discussed in terms of a feedback mechanism controlling the pituitary-testis axis regulation.
在本研究中，对7名健康、休息充分的成年男性的血浆性激素结合球蛋白（SHBG）结合能力的每日变化以及血浆睾酮和促黄体生成素（LH）浓度进行了测定。血浆SHBG结合能力呈现出显著的昼夜节律（高峰相位 = 下午2:06；中值 = 0.35 +/- 0.6 ng睾酮结合/100 ml；振幅 = 中值的17%）。血浆睾酮也显示出昼夜节律（高峰相位 = 上午7:02；中值 = 4.38 +/- 0.67 ng/ml；振幅 = 中值的18%）。游离睾酮指数（即血浆睾酮与SHBG结合能力之间的比值）与血浆LH水平无关。在我们的研究中，最后这个参数并没有按照昼夜模式变化。根据控制垂体 - 睾丸轴调节的反馈机制对这些数据进行了讨论。
