Bai Ning, Wang Nan, Chen Ya, Zhu Jian
Department of Endocrinology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province 214000, China.
Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu Province 214122, China.
JCEM Case Rep. 2025 May 21;3(7):luaf086. doi: 10.1210/jcemcr/luaf086. eCollection 2025 Jul.
Euglycemic diabetic ketoacidosis (EDKA) is a type of DKA whose incidence has increased in recent years because of the widespread use of sodium-glucose transport protein 2 inhibitors in diabetes treatment. However, the concomitant occurrence of a thyroid storm is uncommon, easily misdiagnosed and missed, and has a high risk of death. This report described the case of a 46-year-old woman with type 2 diabetes mellitus who used a sodium-glucose transport protein 2 inhibitor to manage her blood glucose levels. Before undergoing hysteroscopic surgery for a uterine mass, she developed EDKA and thyroid storm after experiencing nausea, vomiting, and a high fever with persistent tachycardia. This report summarizes and analyzes the clinical characteristics, diagnosis, and treatment process and outcomes to accumulate clinical experience and improve clinicians' understanding of this acute and life-threatening disease. Timely and appropriate treatment may help reduce the incidence of morbidity and mortality associated with EDKA and thyroid storm.
正常血糖性糖尿病酮症酸中毒（EDKA）是糖尿病酮症酸中毒（DKA）的一种类型，近年来，由于钠-葡萄糖协同转运蛋白2抑制剂在糖尿病治疗中的广泛应用，其发病率有所上升。然而，甲状腺危象与之同时发生的情况并不常见，容易被误诊和漏诊，且死亡风险很高。本报告描述了一名46岁2型糖尿病女性患者的病例，该患者使用钠-葡萄糖协同转运蛋白2抑制剂来控制血糖水平。在因子宫肿物接受宫腔镜手术前，她在出现恶心、呕吐、高热及持续性心动过速后发生了EDKA和甲状腺危象。本报告总结并分析了其临床特征、诊断、治疗过程及结果，以积累临床经验并提高临床医生对这种急性危及生命疾病的认识。及时、恰当的治疗可能有助于降低与EDKA和甲状腺危象相关的发病率和死亡率。
