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钠-葡萄糖协同转运蛋白2抑制剂使用与冠状动脉造影诱发的正常血糖性糖尿病酮症酸中毒:一例报告

Euglycemic Diabetic Ketoacidosis Induced by Sodium-Glucose Cotransporter-2 Inhibitor Use and Coronary Angiography: A Case Report.

作者信息

VonTungeln Christopher D, Al Bataineh Mohammad

机构信息

Internal Medicine, University of Missouri Health Care, Columbia, USA.

Internal Medicine, University of Missouri Columbia, Columbia, USA.

出版信息

Cureus. 2024 Jan 11;16(1):e52122. doi: 10.7759/cureus.52122. eCollection 2024 Jan.

Abstract

Euglycemic diabetic ketoacidosis (EDKA) is an uncommon subtype of diabetic ketoacidosis (DKA) which presents with similar laboratory findings to classic DKA with the exception of blood glucose levels being under 250 mg/dl. EDKA has several etiologies including pregnancy, starvation and the use of sodium-glucose cotransporter-2 inhibitors (SGLT-2). SGLT-2 inhibitors such as empagliflozin and dapagliflozin are increasing in popularity due to their positive benefits for patients with diabetes mellitus and cardiac disease. EDKA is underdiagnosed as it presents with blood sugar levels lower than expected in classic DKA. This case report describes a well-controlled type 2 diabetic patient prescribed an SGLT-2 inhibitor who developed EDKA after undergoing coronary angiography for acute heart failure.

摘要

正常血糖性糖尿病酮症酸中毒(EDKA)是糖尿病酮症酸中毒(DKA)的一种罕见亚型,其实验室检查结果与经典DKA相似,但血糖水平低于250mg/dl。EDKA有多种病因,包括妊娠、饥饿以及使用钠-葡萄糖协同转运蛋白2抑制剂(SGLT-2)。恩格列净和达格列净等SGLT-2抑制剂因其对糖尿病和心脏病患者的积极益处而越来越受欢迎。由于EDKA患者的血糖水平低于经典DKA患者的预期,因此该病常被漏诊。本病例报告描述了一名2型糖尿病控制良好的患者,该患者在因急性心力衰竭接受冠状动脉造影后,因服用SGLT-2抑制剂而发生了EDKA。

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