Sengupta Shantanu P, Kini Prayag
Sengupta Hospital and Research Institute, Nagpur, Maharashtra.
Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.
Curr Opin Cardiol. 2025 Sep 1;40(5):335-342. doi: 10.1097/HCO.0000000000001236. Epub 2025 May 21.
Cardiac amyloidosis is characterized by systolic and diastolic abnormalities due to deposition of amyloid fibril within the myocardial extracellular space. Technological advances in multimodality cardiac imaging now helps in accurate diagnosis and prognosis of this disease. With technological advances in imaging, it is now easier to follow up these patients whether they are getting response to therapy.
Left ventricular global longitudinal strain assessment is an important noninvasive tool to track response to treatment in cardiac amyloidosis patient.
Present era has shown the importance of using multimodality imaging to understand the pathophysiology of this disease which has been supplemented by both imaging and blood biomarkers. These help in prognosticating the disease burden and to assess treatment response. Future research is now focused on the use of artificial intelligence and precision medicine to detect of changes earlier in the course of treatment.
心脏淀粉样变性的特征是由于淀粉样纤维沉积在心肌细胞外间隙而导致的收缩和舒张功能异常。多模态心脏成像技术的进步现在有助于对这种疾病进行准确的诊断和预后评估。随着成像技术的进步，现在更容易对这些患者进行随访，以了解他们是否对治疗有反应。
左心室整体纵向应变评估是追踪心脏淀粉样变性患者治疗反应的重要非侵入性工具。
当前时代已经表明使用多模态成像来理解这种疾病病理生理学的重要性，这已得到成像和血液生物标志物的补充。这些有助于预测疾病负担和评估治疗反应。未来的研究现在集中在使用人工智能和精准医学来更早地检测治疗过程中的变化。
