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开展并评估一项关于利益冲突及企业对科学的影响的教育干预措施。

Developing and evaluating an educational intervention on conflicts of interest and corporate influence on science.

作者信息

Fabbri Alice, Fitzpatrick Iona, Braznell Sophie, Legg Tess, Cliffe Emma, Vance Filipa, Topley Dale, Baber Fran, Gilmore Anna B

机构信息

Department for Health, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

Mathematics Resources Centre, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

出版信息

Health Promot Int. 2025 May 13;40(3). doi: 10.1093/heapro/daaf059.

Abstract

Financial conflicts of interest resulting from corporate funding of research can bias the evidence base. We designed an educational intervention that sought to enable participants to make informed decisions and mitigate risk when considering corporate funding for research. We used pre/post-test surveys, which comprised a mix of closed and open-ended questions, to evaluate the training and its impact on knowledge (Wilcoxon signed-rank test), attitudes and perceptions (Friedman's test with planned post hoc tests). Open-ended questions were coded and key themes identified. Twenty participants from the University of Bath (15 PhD students and 5 research staff) completed the pre-test survey and attended the training, 17 filled in the post-test survey, and 17 filled in the 3-month follow-up survey. All participants agreed or strongly agreed that the issues relating to conflict of interest presented in the training increased their interest in the topic. Participants' knowledge significantly increased between the pre and post-measures. Awareness of institutional conflict of interest policies and participants' confidence in mitigating the risks of corporate funding also significantly improved. For the other measures of impact, either there was not a statistically significant difference between the pre, post, and follow-up measures or there was, but post hoc tests were not significant after a Bonferroni correction. Our findings indicate that even a short educational intervention could increase researchers' confidence in and ability to make informed decisions about whether to accept corporate funding and under what conditions.

摘要

企业资助研究产生的经济利益冲突会使证据基础产生偏差。我们设计了一项教育干预措施,旨在使参与者在考虑企业资助研究时能够做出明智的决策并降低风险。我们使用了前后测试调查,其中包括封闭式和开放式问题的混合,以评估培训及其对知识(威尔科克森符号秩检验)、态度和认知(弗里德曼检验及计划的事后检验)的影响。对开放式问题进行编码并确定关键主题。来自巴斯大学的20名参与者(15名博士生和5名研究人员)完成了预测试调查并参加了培训,17人填写了后测试调查,17人填写了3个月的随访调查。所有参与者都同意或强烈同意培训中提出的与利益冲突相关的问题增加了他们对该主题的兴趣。参与者的知识在前后测量之间显著增加。对机构利益冲突政策的认识以及参与者减轻企业资助风险的信心也显著提高。对于其他影响指标,要么在预测试、后测试和随访测量之间没有统计学上的显著差异,要么有差异,但在进行邦费罗尼校正后事后检验不显著。我们的研究结果表明,即使是短暂的教育干预也可以增强研究人员在是否接受企业资助以及在何种条件下接受资助方面做出明智决策的信心和能力。

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