Giri Prashant S, Patel Shivani, Thakor Foram, Dwivedi Mitesh
C. G. Bhakta Institute of Biotechnology, Faculty of Science, Uka Tarsadia University, Bardoli, Surat, India.
Department of Immunology, St. Jude Children's Hospital, Memphis, TN, USA.
Expert Rev Clin Immunol. 2025 Jun;21(6):761-774. doi: 10.1080/1744666X.2025.2510491. Epub 2025 May 26.
Vitiligo is a chronic autoimmune skin depigmenting condition. IFN-γ, TNF-α and granzyme B play key roles in vitiligo pathogenesis, some findings suggest their roles may be contradictory.
We aimed to assess IFN-γ, TNF-α and granzyme B levels in blood and skin of vitiligo patients using a meta-analysis approach. Additionally, we evaluated their association with disease activity.
A Meta-analysis was conducted using Review Manager 5.4 software. A total of 55 studies including 3,023 vitiligo patients and 2,534 controls were included in the study.
Pooled results from our meta-analysis indicated significantly elevated IFN-γ protein and transcript levels in blood and skin of vitiligo patients ( < 0.05). TNF-α protein levels were also significantly increased in blood and skin of vitiligo patients ( < 0.05). IFN-γ and TNF-α levels were significantly higher in the lesional skin as compared to non-lesional skin ( < 0.05). Furthermore, elevated levels of IFN-γ and TNF-α were observed in patients with active vitiligo ( < 0.05). Additionally, our study suggested a significant increase in granzyme B levels in vitiligo patients ( < 0.05).
Overall, the meta-analysis suggests that IFN-γ, TNF-α and granzyme B play a crucial role in vitiligo pathogenesis and progression and may serve as potential therapeutic targets for managing the disease. The PROSPERO registration no. for meta-analysis is CRD42024620274.
白癜风是一种慢性自身免疫性皮肤色素脱失性疾病。干扰素-γ（IFN-γ）、肿瘤坏死因子-α（TNF-α）和颗粒酶B在白癜风发病机制中起关键作用，一些研究结果表明它们的作用可能相互矛盾。
我们旨在采用荟萃分析方法评估白癜风患者血液和皮肤中IFN-γ、TNF-α和颗粒酶B的水平。此外，我们还评估了它们与疾病活动度的相关性。
使用Review Manager 5.4软件进行荟萃分析。本研究共纳入55项研究，包括3023例白癜风患者和2534例对照。
我们荟萃分析的汇总结果表明，白癜风患者血液和皮肤中IFN-γ蛋白和转录水平显著升高（<0.05）。白癜风患者血液和皮肤中的TNF-α蛋白水平也显著升高（<0.05）。与非皮损皮肤相比，皮损皮肤中IFN-γ和TNF-α水平显著更高（<0.05）。此外，活动期白癜风患者中观察到IFN-γ和TNF-α水平升高（<0.05）。此外，我们的研究表明白癜风患者颗粒酶B水平显著升高（<0.05）。
总体而言，荟萃分析表明IFN-γ、TNF-α和颗粒酶B在白癜风发病机制和进展中起关键作用，可能作为治疗该疾病的潜在靶点。荟萃分析的PROSPERO注册号为CRD42024620274。
