Hand T H, Franklin K B
Neurosci Lett. 1985 Apr 19;55(3):367-70. doi: 10.1016/0304-3940(85)90463-x.
Selective lesions of the dopamine (DA) neurons of the ventral tegmental area (VTA) were found to substantially delay the development of tolerance to morphine-induced catalepsy, in comparison with sham-operated controls receiving morphine. Lesioned subjects receiving vehicle injections showed no catalepsy. The data suggest that tolerance to morphine catalepsy requires intact VTA DA neurons. Furthermore, since the acute cataleptic response was intact in lesioned animals, the data suggest that the mechanisms involved in the cataleptic response to morphine are dissociable from those which bring about tolerance to that response.
与接受吗啡的假手术对照组相比，发现腹侧被盖区（VTA）多巴胺（DA）神经元的选择性损伤会显著延迟对吗啡诱导的僵住症耐受性的发展。接受赋形剂注射的损伤受试者未出现僵住症。数据表明，对吗啡僵住症的耐受性需要完整的VTA DA神经元。此外，由于损伤动物的急性僵住症反应是完整的，数据表明，对吗啡的僵住症反应所涉及的机制与导致对该反应产生耐受性的机制是可分离的。
