Li Wenhua, Ma Suya, Li Min
State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education Key Laboratory of Pharmacologyof, Traditional Chinese Medicine Formulae, Institute of Traditional Chinese Medicine , Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Guang'anmen Hospital, China, Academy of Chinese Medicine Sciences , Beijing, 100053, China.
Mol Neurobiol. 2025 May 22. doi: 10.1007/s12035-025-05028-8.
Neurogenesis is a biological process in which new neurons are generated from neural stem cells (NSCs) in specific neural niches in the brain. Impaired neurogenesis, characterized by the progressive loss of neurons, leads to cognitive and motor disabilities and is a hallmark of central nervous system (CNS) diseases. Conversely, enhancing neurogenesis has been shown to alleviate the symptoms of CNS diseases. Apolipoprotein E (APOE) is a protein that plays various biological roles in CNS diseases. Emerging research indicates that APOE is involved in adult neurogenesis, which is crucial for maintaining the neural progenitor pool in the dentate gyrus (DG) and synaptic activity. Therefore, APOE could be a therapeutic target for promoting neurogenesis in the treatment and intervention of CNS diseases. In this context, we present a comprehensive overview of the clinical evidence supporting the role of APOE in CNS diseases on the basis of a meta-analysis. We also discuss the neurogenic potential of APOE, which has significant implications not only for understanding the biological underpinnings of neurological diseases but also for developing novel treatment strategies for CNS diseases.
神经发生是一个生物学过程，在此过程中，新的神经元由大脑特定神经微环境中的神经干细胞（NSCs）产生。神经发生受损，其特征是神经元逐渐丧失，会导致认知和运动功能障碍，并且是中枢神经系统（CNS）疾病的一个标志。相反，已证明增强神经发生可缓解CNS疾病的症状。载脂蛋白E（APOE）是一种在CNS疾病中发挥多种生物学作用的蛋白质。新出现的研究表明，APOE参与成年神经发生，这对于维持齿状回（DG）中的神经祖细胞池和突触活动至关重要。因此，在CNS疾病的治疗和干预中，APOE可能是促进神经发生的治疗靶点。在此背景下，我们基于一项荟萃分析，全面概述了支持APOE在CNS疾病中作用的临床证据。我们还讨论了APOE的神经发生潜力，这不仅对理解神经疾病的生物学基础具有重要意义，而且对开发CNS疾病的新治疗策略也具有重要意义。
