Murakami S, Igarashi T, Takahara M, Yamanishi T, Shimazaki J, Shigematsu H
Hinyokika Kiyo. 1985 Feb;31(2):301-7.
Urocystic mucosal biopsies of the white patch on the trigone in 44 women complaining of dysuria and frequency with or without bacteriuria showed varying degrees of squamous metaplasia as well as submucosal fibrosis. The patients with more frequent episodes of such symptoms in the past had more severe squamous metaplasia with submucosal fibrosis. Introital bacteria were found in almost all patients with mild or moderate development of squamous metaplasia, but not in those with severe lesions. These facts suggest that introital bacteria may be one of the causative factors for the initiation and early development of these abnormal mucosal changes. However, the further progression to severe mucosal alteration seems to be independent of any bacteria and this severe mucosal alteration may result in recurrence of such symptoms.
对44名主诉排尿困难、尿频且伴有或不伴有菌尿的女性膀胱三角区白色斑块进行膀胱黏膜活检，结果显示存在不同程度的鳞状化生以及黏膜下纤维化。过去此类症状发作更频繁的患者，鳞状化生及黏膜下纤维化更严重。在几乎所有鳞状化生呈轻度或中度发展的患者中都发现了阴道口细菌，但在病变严重的患者中未发现。这些事实表明，阴道口细菌可能是这些异常黏膜变化起始和早期发展的致病因素之一。然而，黏膜病变进一步发展至严重程度似乎与任何细菌无关，这种严重的黏膜改变可能导致此类症状复发。
