Matsuoka R, Kira S, Watanabe S, Nagao K, Inatomi K, Honma H
Gan To Kagaku Ryoho. 1985 Jul;12(7):1407-12.
The effects of chemotherapy by single administration of Cisplatin were studied in 26 patients with non-small cell carcinoma of the lung. There were 22 males and 4 females with a median age of 63 years. 21 cases were epidermoid carcinoma, 4 cases were adenocarcinoma and 1 case was atypical carcinoid. Cisplatin 20 mg/m2 with hydration and diuresis was given daily for 5 consecutive days. The course was repeated every 3 weeks. Partial response was observed in 4 patients (3 epidermoid carcinoma and one atypical carcinoid). The response rate was 19%. Side effects induced by Cisplatin were gastrointestinal toxicity including vomiting, nausea and appetite less, bone marrow toxicity and renal damage. These were not so severe, and reversible. Gastrointestinal toxicities were controlled successfully by corticosteroids. In 12 patients gastrointestinal toxicities were not observed. We conclude that Cisplatin is effective for non-small cell carcinoma, especially for epidermoid carcinoma. Hematologic toxicities of Cisplatin were not so severe. Therefore, combination chemotherapy including Cisplatin would improve the quality of life of patients suffering from non-small cell carcinoma of the lung.
对26例非小细胞肺癌患者进行了单次给予顺铂化疗效果的研究。其中男性22例，女性4例，中位年龄63岁。21例为鳞状细胞癌，4例为腺癌，1例为非典型类癌。每日给予顺铂20mg/m²，同时进行水化和利尿，连续给药5天。每3周重复一个疗程。4例患者（3例鳞状细胞癌和1例非典型类癌）出现部分缓解。缓解率为19%。顺铂引起的副作用包括胃肠道毒性，如呕吐、恶心和食欲减退、骨髓毒性和肾损害。这些副作用不太严重，且可逆转。胃肠道毒性通过皮质类固醇成功控制。12例患者未观察到胃肠道毒性。我们得出结论，顺铂对非小细胞肺癌有效，尤其是对鳞状细胞癌。顺铂的血液学毒性不太严重。因此，包含顺铂的联合化疗将改善非小细胞肺癌患者的生活质量。
