Buckley A R, Putnam C W, Russell D H
Biochim Biophys Acta. 1985 Jul 26;841(1):127-30. doi: 10.1016/0304-4165(85)90282-x.
Rapid and substantial elevations in ornithine decarboxylase and plasminogen activator have been linked to tumor promotion in mouse epidermis and in vitro. Systemic administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) rapidly increased both enzymic activities in rat liver. Pretreatment with either cycloheximide or actinomycin D attenuated both enzyme inductions. It is concluded that: (1) systemic TPA rapidly induces plasminogen activator and ornithine decarboxylase activities in rat liver; and (2) both inductions reflect de novo enzyme synthesis.
鸟氨酸脱羧酶和纤溶酶原激活剂的快速大幅升高与小鼠表皮及体外的肿瘤促进作用有关。全身给予12 - O - 十四烷酰佛波醇13 - 乙酸酯（TPA）可使大鼠肝脏中的这两种酶活性迅速增加。用环己酰亚胺或放线菌素D预处理可减弱这两种酶的诱导作用。得出以下结论：（1）全身给予TPA可迅速诱导大鼠肝脏中的纤溶酶原激活剂和鸟氨酸脱羧酶活性；（2）这两种诱导作用均反映了酶的从头合成。
