[肿瘤内微生物群与肺癌关系的研究进展]
[Research Progress on the Relationship between Intratumor Microbiota and Lung Cancer].
作者信息
Zhu Yangtong, Chen Jiawei, Zhu Yanqian, Wu Linyu
机构信息
The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), First Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou 310006, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2025 Apr 20;28(4):304-308. doi: 10.3779/j.issn.1009-3419.2025.101.05.
Lung cancer has the highest incidence and mortality of any cancer in the world. In recent years, with the development of microbial detection technology, the intratumor microbiota has gradually become a hot spot and frontier in the field of lung cancer research. Studies have found that the microbiota present in tumors can influence the development of lung cancer in a variety of ways. In addition, the intratumor microbiota can be used as a potential biomarker for the diagnosis and prognosis assessment of lung cancer, and the regulation of the intratumor microbiota of lung cancer is expected to become a new type of lung cancer treatment. In this paper, we reviewed the latest research progress on the relationship between intratumor microbiota and lung cancer, summarized the origin and characteristics of intratumor microbiota, discussed the mechanism of its influence on the occurrence and development of lung cancer, and explored its potential applications in the diagnosis, treatment and prognosis of lung cancer. .
肺癌是全球所有癌症中发病率和死亡率最高的。近年来，随着微生物检测技术的发展，肿瘤内微生物群逐渐成为肺癌研究领域的热点和前沿。研究发现，肿瘤中存在的微生物群可以多种方式影响肺癌的发展。此外，肿瘤内微生物群可用作肺癌诊断和预后评估的潜在生物标志物，对肺癌肿瘤内微生物群的调节有望成为一种新型的肺癌治疗方法。在本文中，我们综述了肿瘤内微生物群与肺癌关系的最新研究进展，总结了肿瘤内微生物群的来源和特征，讨论了其影响肺癌发生发展的机制，并探讨了其在肺癌诊断、治疗和预后方面的潜在应用。
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