Li Lexin, Cui Xuyang, Lin Zhanyu, Chen Yiming, Zhang Xiaoyu, Zhu Yong
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, 4655 University Road, Changqing District, Jinan, 250000, Shangdong Province, China.
Medical College, Shandong University of Traditional Chinese Medicine, 4655 University Road, Changqing District, Jinan, 250000, Shangdong Province, China.
Discov Oncol. 2025 May 22;16(1):860. doi: 10.1007/s12672-025-02719-5.
Colorectal cancer (CRC) remains a malignancy with high incidence and mortality rates worldwide, necessitating the development of more effective therapeutic strategies due to the limitations of current treatments, including drug resistance and adverse effects. Scutellaria baicalensis, a traditional Chinese medicinal herb, contains baicalin and baicalein as its primary bioactive flavonoids, which exhibit notable pharmacological properties such as antibacterial, anti-inflammatory, antioxidant, and antitumor effects. Recent studies have demonstrated that baicalin and baicalein show promising antitumor activity in CRC treatment through mechanisms such as scavenging reactive oxygen species, immune regulation, and inhibition of tumor cell proliferation, induction of apoptosis, and modulation of the gut microenvironment. This study further investigates the molecular mechanisms underlying the therapeutic effects of baicalin and baicalein in CRC, aiming to provide new research perspectives and potential clinical applications for the integration of flavonoid-based compounds from Scutellaria baicalensis in CRC treatment.
结直肠癌（CRC）在全球范围内仍然是一种发病率和死亡率都很高的恶性肿瘤，由于包括耐药性和不良反应在内的现有治疗方法存在局限性，因此需要开发更有效的治疗策略。黄芩是一种传统中药，其主要生物活性黄酮类化合物为黄芩苷和黄芩素，它们具有显著的药理特性，如抗菌、抗炎、抗氧化和抗肿瘤作用。最近的研究表明，黄芩苷和黄芩素通过清除活性氧、免疫调节、抑制肿瘤细胞增殖、诱导凋亡以及调节肠道微环境等机制，在CRC治疗中显示出有前景的抗肿瘤活性。本研究进一步探讨黄芩苷和黄芩素在CRC治疗中的分子机制，旨在为将黄芩中基于黄酮类的化合物整合到CRC治疗中提供新的研究视角和潜在的临床应用。
