Kim D S, Moon H, Kang K J
Gynecol Oncol. 1985 Sep;22(1):59-64. doi: 10.1016/0090-8258(85)90008-3.
Two cases with squamous cell carcinoma of the cervix stage IIB with primary tumor mass about 2 X 2 X 2 cm were treated with primary chemotherapy of cis-platinum, 20 micrograms/m2 body surface intravenously daily for 5 consecutive days. Papanicolaou smear turned negative after two courses of chemotherapy in both cases. One of those was followed by radical hysterectomy with lymphadenectomy which confirmed that there was no evidence of disease by histopathology. The third case with stage IIIB and bulky tumor with involvement of pelvic and left common iliac lymph nodes was treated with simple hysterectomy followed by adjuvant chemotherapy with the same medication described above. Complete responses were obtained in all three cases and they are now doing well in a tumor-free state for 26, 30, and 28 months, respectively.
两例宫颈鳞状细胞癌IIB期患者，原发肿瘤肿块约2×2×2厘米，接受了顺铂为主的初始化疗，静脉注射剂量为20微克/平方米体表面积，每日1次，连续5天。两例患者在两个疗程化疗后巴氏涂片均转为阴性。其中1例随后接受了根治性子宫切除术及淋巴结清扫术，组织病理学检查证实无疾病证据。第三例IIIB期患者，肿瘤体积较大，累及盆腔及左髂总淋巴结，接受了单纯子宫切除术，随后采用上述相同药物进行辅助化疗。所有三例患者均获得完全缓解，目前分别处于无瘤状态26个月、30个月和28个月，情况良好。
