不同宫颈部位的人乳头瘤病毒相关鳞状细胞癌和腺癌：一例报告

HPV-associated squamous cell carcinoma and adenocarcinoma in distinct cervical sites: a case report.

作者信息

Chen Huihui, Wang Qingyi, Kang Min, Huang Wei, Zhang Hao, Li Jiaxin, Xu Donghan, Zhao Lin, Wu Bowen, Lin Xin, Li Liqi, Zheng Yuhong, Niu Yihao, Zhou Jiaqi, Huang Donghui, Yan Peiyu

机构信息

Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.

Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, 208 Yuehua Road, Xiangzhou District, Zhuhai, 519000, Guangdong province, China.

出版信息

BMC Infect Dis. 2025 May 22;25(1):732. doi: 10.1186/s12879-025-11114-y.

DOI:10.1186/s12879-025-11114-y

PMID:40405116

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12101027/

Abstract

BACKGROUND

The synchronous occurrence of adenocarcinoma and squamous cell carcinoma in distinct cervical regions is exceptionally rare. This report highlights a case of HPV-associated adenocarcinoma and squamous cell carcinoma at distinct sites in a patient with primary stage IA1 cervical cancer.

CASE PRESENTATION

A 54-year-old female tested HPV type 18 positive in a routine physical exam. Cervical Liquid - based Cytology Test (LCT) showed Atypical Squamous Cells of Undetermined Significance (ASCUS). Colposcopy-directed biopsies revealed moderately differentiated squamous cell carcinoma at multiple sites (3, 6, 9, 12 o'clock positions and the ECC), with a clinical diagnosis of stage IA1. Preoperative abdominal MRI (including contrast enhancement) showed no lymph node enlargement, and urinary CT urography was normal. Squamous cell carcinoma antigen levels were within the normal range.

摘要

背景

腺癌和鳞状细胞癌在不同宫颈区域同步发生极为罕见。本报告重点介绍了一名IA1期宫颈癌患者在不同部位出现人乳头瘤病毒（HPV）相关腺癌和鳞状细胞癌的病例。

病例介绍

一名54岁女性在常规体检中检测出HPV 18型呈阳性。宫颈液基细胞学检测（LCT）显示意义不明确的非典型鳞状细胞（ASCUS）。阴道镜引导下活检显示多个部位（3、6、9、12点位置及宫颈管内膜）存在中分化鳞状细胞癌，临床诊断为IA1期。术前腹部磁共振成像（包括增强扫描）显示无淋巴结肿大，泌尿系统CT尿路造影正常。鳞状细胞癌抗原水平在正常范围内。