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不同宫颈部位的人乳头瘤病毒相关鳞状细胞癌和腺癌：一例报告

HPV-associated squamous cell carcinoma and adenocarcinoma in distinct cervical sites: a case report.

作者信息

Chen Huihui, Wang Qingyi, Kang Min, Huang Wei, Zhang Hao, Li Jiaxin, Xu Donghan, Zhao Lin, Wu Bowen, Lin Xin, Li Liqi, Zheng Yuhong, Niu Yihao, Zhou Jiaqi, Huang Donghui, Yan Peiyu

机构信息

Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.

Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, 208 Yuehua Road, Xiangzhou District, Zhuhai, 519000, Guangdong province, China.

出版信息

BMC Infect Dis. 2025 May 22;25(1):732. doi: 10.1186/s12879-025-11114-y.

DOI:10.1186/s12879-025-11114-y
PMID:40405116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12101027/
Abstract

BACKGROUND

The synchronous occurrence of adenocarcinoma and squamous cell carcinoma in distinct cervical regions is exceptionally rare. This report highlights a case of HPV-associated adenocarcinoma and squamous cell carcinoma at distinct sites in a patient with primary stage IA1 cervical cancer.

CASE PRESENTATION

A 54-year-old female tested HPV type 18 positive in a routine physical exam. Cervical Liquid - based Cytology Test (LCT) showed Atypical Squamous Cells of Undetermined Significance (ASCUS). Colposcopy-directed biopsies revealed moderately differentiated squamous cell carcinoma at multiple sites (3, 6, 9, 12 o'clock positions and the ECC), with a clinical diagnosis of stage IA1. Preoperative abdominal MRI (including contrast enhancement) showed no lymph node enlargement, and urinary CT urography was normal. Squamous cell carcinoma antigen levels were within the normal range.

摘要

背景

腺癌和鳞状细胞癌在不同宫颈区域同步发生极为罕见。本报告重点介绍了一名IA1期宫颈癌患者在不同部位出现人乳头瘤病毒（HPV）相关腺癌和鳞状细胞癌的病例。

病例介绍

一名54岁女性在常规体检中检测出HPV 18型呈阳性。宫颈液基细胞学检测（LCT）显示意义不明确的非典型鳞状细胞（ASCUS）。阴道镜引导下活检显示多个部位（3、6、9、12点位置及宫颈管内膜）存在中分化鳞状细胞癌，临床诊断为IA1期。术前腹部磁共振成像（包括增强扫描）显示无淋巴结肿大，泌尿系统CT尿路造影正常。鳞状细胞癌抗原水平在正常范围内。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0d/12101027/19ef43a4d1d2/12879_2025_11114_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0d/12101027/a5849c0a2f17/12879_2025_11114_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0d/12101027/19ef43a4d1d2/12879_2025_11114_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0d/12101027/a5849c0a2f17/12879_2025_11114_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0d/12101027/2a64d3fe5ed7/12879_2025_11114_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0d/12101027/d9c2cea7dc77/12879_2025_11114_Fig3_HTML.jpg
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本文引用的文献

1
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Nat Commun. 2024 Nov 22;15(1):10114. doi: 10.1038/s41467-024-53830-0.
2
Cervical Cancer Screening: A Review.宫颈癌筛查：综述。
JAMA. 2023 Aug 8;330(6):547-558. doi: 10.1001/jama.2023.13174.
3
HPV genotyping of cervical histologic specimens of 61, 422 patients from the largest women hospital in China.对来自中国最大的女子医院的61422名患者的宫颈组织学标本进行人乳头瘤病毒基因分型。
Front Oncol. 2023 Mar 29;13:1161631. doi: 10.3389/fonc.2023.1161631. eCollection 2023.
4
Cancer statistics, 2023.癌症统计数据，2023 年。
CA Cancer J Clin. 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763.
5
RNA N-methyladenosine modification mediates downregulation of NR4A1 to facilitate malignancy of cervical cancer.RNA N-甲基腺苷修饰介导NR4A1的下调以促进宫颈癌的恶性进展。
Cell Biosci. 2022 Dec 25;12(1):207. doi: 10.1186/s13578-022-00937-w.
6
Cells with stem-like properties are associated with the development of HPV18-positive cervical cancer.具有干细胞样特性的细胞与 HPV18 阳性宫颈癌的发展有关。
Cancer Sci. 2023 Mar;114(3):885-895. doi: 10.1111/cas.15664. Epub 2022 Dec 9.
7
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.《全球癌症统计数据 2020：全球 185 个国家和地区 36 种癌症的发病率和死亡率估计》。
CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4.
8
Delta-Like Ligand-Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis.Delta 样配体-Notch1 信号受 HPV16 E6 选择性调节以促进鳞状细胞增殖，并与宫颈癌预后相关。
Cancer Res. 2021 Apr 1;81(7):1909-1921. doi: 10.1158/0008-5472.CAN-20-1996. Epub 2021 Jan 26.
9
Gencore: an efficient tool to generate consensus reads for error suppressing and duplicate removing of NGS data.Gencore：一种高效的工具，用于生成共识读数，以抑制 NGS 数据的错误并去除重复。
BMC Bioinformatics. 2019 Dec 27;20(Suppl 23):606. doi: 10.1186/s12859-019-3280-9.
10
fastp: an ultra-fast all-in-one FASTQ preprocessor.fastp：一个超快速的一体化 FASTQ 预处理程序。
Bioinformatics. 2018 Sep 1;34(17):i884-i890. doi: 10.1093/bioinformatics/bty560.