Kadziolka A, Koper S, Mierzejewski T, Rubaj B, Rucinski T, Kraeling R R
J Anim Sci. 1985 Jun;60(6):1619-30. doi: 10.2527/jas1985.6061619x.
Sows and gilts of the Great White Polish (GWP) breed were classified into groups of 10 each: gilts 8 mo of age (A), sows over 1 yr old with an average litter size of five (BI) and eleven (BII), 2- to 3-yr-old sows with an average litter size of five (CI) and nine (CII), 4- to 6-yr-old sows with an average litter size of six (DI) and nine (DII). Gilts of group A were necropsied on d 10 of the estrous cycle while sows were necropsied 120 to 360 d postpartum. A blood sample obtained by vena cava puncture immediately before exsanguination was quantitated for total cholesterol, free cholesterol, cholesterol ester, total lipid, triglyceride, high and low density lipoprotein and chylomicrons. Postmortem angiograms of the uterine vasculature were evaluated for occurrence of arteriosclerotic lesions of the arteries and their branches. Sections of blood vessels from areas of restriction were examined histologically and quantitated for lipids and proteolytic and lipolytic enzyme activities. With the exception of high density lipoproteins and chylomicrons, serum concentrations of various lipids increased (P less than .01) with age. Restrictions of the lumen were found in uterine arteries and their branches of most gilts in group A and in sows in groups B, C and D, irrespective of litter size. Histology of uterine artery revealed preatherosclerotic lesions in groups B through D. No relationship between the incidence and degree of sclerotic lesions and litter size was evident. However, the incidence and degree of sclerotic lesions increased with age and parity. Results from histopathology were supported by results from measurement of lipids and enzyme activities of the uterine artery wall. Conception rates of sows in groups C and D were lower than those of group B. Many of these sows (70%) failed to conceive during 1 yr even though they displayed normal estrous cycles.
大白波兰（GWP）品种的母猪和后备母猪被分为每组10头的群体：8月龄后备母猪（A组），平均产仔数为5头的1岁以上母猪（BI组）和11头的（BII组），平均产仔数为5头的2至3岁母猪（CI组）和9头的（CII组），平均产仔数为6头的4至6岁母猪（DI组）和9头的（DII组）。A组后备母猪在发情周期的第10天进行剖检，而母猪在产后120至360天进行剖检。在放血前立即通过腔静脉穿刺采集血样，对总胆固醇、游离胆固醇、胆固醇酯、总脂质、甘油三酯、高密度和低密度脂蛋白以及乳糜微粒进行定量分析。对子宫血管系统的死后血管造影进行评估，以检查动脉及其分支的动脉硬化病变的发生情况。对来自狭窄区域的血管切片进行组织学检查，并对脂质以及蛋白水解酶和脂解酶活性进行定量分析。除了高密度脂蛋白和乳糜微粒外，各种脂质的血清浓度随年龄增长而升高（P<0.01）。在A组的大多数后备母猪以及B、C和D组的母猪的子宫动脉及其分支中均发现管腔狭窄，与产仔数无关。子宫动脉组织学检查显示B至D组存在动脉粥样硬化前期病变。硬化病变的发生率和程度与产仔数之间没有明显关系。然而，硬化病变的发生率和程度随年龄和胎次增加而增加。组织病理学结果得到子宫动脉壁脂质和酶活性测量结果的支持。C组和D组母猪的受胎率低于B组。这些母猪中有许多（70%）即使发情周期正常，在1年内也未能受孕。
