Murata M, Imaizumi K, Sugano M
J Nutr. 1985 Aug;115(8):994-1004. doi: 10.1093/jn/115.8.994.
Previous research has shown that serum cholesterol and apolipoprotein (apo) A-I were lower and serum apoB was higher in rats fed soybean phospholipid (PL) than in rats fed soybean oil. Secretion of cholesterol and apoA-I, but not apoB, from the liver and intestine was lower in rats fed soybean PL. In the present study catabolism of newly formed triglyceride (TG)-rich lipoproteins, from the liver and intestine, and of serum high density lipoproteins (HDL) were compared in rats fed soybean PL and in rats fed soybean oil. The following results were seen: Feeding of soybean PL was related to more TG and less cholesterol in intestinal lymph chylomicrons (CM) and hepatic very low density lipoproteins (VLDL) than was feeding of soybean oil. A lesser amount of the TG, labeled with [3H]oleate in CM and hepatic VLDL, was incorporated into the adipose tissue and muscle in vivo. The clearance of CM-TG from plasma was higher, but that of VLDL-TG and apoB labeled with [3H]lysine was lower. The catabolism of 125I-labeled HDL from the plasma was lower while hepatic uptake of 125I-labeled HDL, in vivo and in vitro, was higher. These results indicate that soybean PL modifies the catabolism of the respective serum lipoproteins. Therefore, we suggest that changes in both the catabolism and secretion of lipoproteins are responsible for the altered serum lipid and apolipoprotein patterns found in rats fed soybean PL.
先前的研究表明，与喂食大豆油的大鼠相比，喂食大豆磷脂（PL）的大鼠血清胆固醇和载脂蛋白（apo）A-I较低，而血清apoB较高。喂食大豆PL的大鼠肝脏和肠道中胆固醇和apoA-I的分泌较低，但apoB的分泌并非如此。在本研究中，比较了喂食大豆PL的大鼠和喂食大豆油的大鼠肝脏和肠道中新形成的富含甘油三酯（TG）的脂蛋白以及血清高密度脂蛋白（HDL）的分解代谢。结果如下：与喂食大豆油相比，喂食大豆PL的大鼠肠道淋巴乳糜微粒（CM）和肝脏极低密度脂蛋白（VLDL）中的TG含量更多，胆固醇含量更少。CM和肝脏VLDL中用[3H]油酸标记的TG较少量在体内被整合到脂肪组织和肌肉中。血浆中CM-TG的清除率较高，但用[3H]赖氨酸标记的VLDL-TG和apoB的清除率较低。血浆中125I标记的HDL的分解代谢较低，而体内和体外肝脏对125I标记的HDL的摄取较高。这些结果表明，大豆PL改变了相应血清脂蛋白的分解代谢。因此，我们认为脂蛋白分解代谢和分泌的变化是喂食大豆PL的大鼠血清脂质和载脂蛋白模式改变的原因。
