Allen L G, Lawrence I E, Burden H W, Hodson C A
J Reprod Fertil. 1985 May;74(1):87-94. doi: 10.1530/jrf.0.0740087.
Vagotomy on the morning of pro-oestrus did not prevent the pro-oestrous LH surge and rats became oestrous on the following day. However, vagotomized rats then exhibited a period of acyclicity which lasted for 20.4 +/- 1.3 (s.e.m.) days. Food intake and body weight also declined after vagotomy. During the first week after vagotomy, afternoon LH surges generally did not occur, a pattern which was similar in animals pair fed with vagotomized rats. However, pair-fed rats showed oestrous cycles while vagotomized rats were acyclic. At 7 days after vagotomy, LH surges were induced by oestradiol benzoate and progesterone treatment of ovariectomized rats. Vagotomy suppressed the post-ovariectomy increase in serum LH at 7 and 21 days after surgery. These results, combined with those of other studies, suggest impairment of LH release in vagotomized rats.
在动情前期的早晨进行迷走神经切断术并不能阻止动情前期促黄体生成素（LH）高峰的出现，大鼠在第二天进入发情期。然而，迷走神经切断术后的大鼠随后出现了一段持续20.4±1.3（标准误）天的无发情周期状态。迷走神经切断术后食物摄入量和体重也下降。在迷走神经切断术后的第一周，下午通常不会出现LH高峰，这种模式在与迷走神经切断术大鼠配对饲养的动物中相似。然而，配对饲养的大鼠表现出发情周期，而迷走神经切断术大鼠则无发情周期。在迷走神经切断术后7天，通过对去卵巢大鼠进行苯甲酸雌二醇和孕酮处理诱导LH高峰。迷走神经切断术抑制了术后7天和21天去卵巢大鼠血清LH的升高。这些结果，结合其他研究的结果，表明迷走神经切断术大鼠中LH释放受损。
