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病例报告:仅表现为膝关节疼痛而无低磷血症的排磷性间叶肿瘤。

Case Report: Phosphaturic mesenchymal tumor presenting solely as knee pain without hypophosphatemia.

作者信息

Cao Qianqian, Cheng Cheng, Dai Zhipeng

机构信息

Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China.

出版信息

Front Oncol. 2025 May 8;15:1597194. doi: 10.3389/fonc.2025.1597194. eCollection 2025.

Abstract

Phosphaturic mesenchymal tumor (PMT) is a rare tumor disease that often leads to tumor-induced osteomalacia (TIO). The typical manifestations of this disease include hypophosphatemia and osteomalacia. The main symptom in most PMT patients is diffuse pain throughout the body. However, we report a PMT patient with typical histological features but without hypophosphatemia and TIO. This patient only presented with pain in the right knee joint. At 6 months and 1 year after surgery, follow-up revealed that the patient's swelling and pain in the right knee joint had disappeared. Moreover, the imaging and biochemical examinations conducted at the local hospital showed normal results.

摘要

磷酸尿性间叶肿瘤(PMT)是一种罕见的肿瘤疾病,常导致肿瘤诱导的骨软化症(TIO)。该疾病的典型表现包括低磷血症和骨软化症。大多数PMT患者的主要症状是全身弥漫性疼痛。然而,我们报告了一名具有典型组织学特征但无低磷血症和TIO的PMT患者。该患者仅表现为右膝关节疼痛。术后6个月和1年的随访显示,患者右膝关节的肿胀和疼痛已消失。此外,当地医院进行的影像学和生化检查结果均正常。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d312/12094952/b0ae841e2cb2/fonc-15-1597194-g001.jpg

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