Mei Aoxue, Xu Ke, Gong Mingkun, Fu Cong, Bo Yujie, Qiao Jiao, Li Tianfu, Wang Mengyang, Wang Xiongfei, Zhou Jian, Guan Yuguang, Luan Guoming
Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Department of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Front Neurol. 2025 May 8;16:1578958. doi: 10.3389/fneur.2025.1578958. eCollection 2025.
This study investigated the differences in semiological characteristics of temporal lobe epilepsy (TLE) between children and adult populations, specifically examining the impact of age on these manifestations. Using multivariate analysis, this study assessed the influence of age on TLE clinical manifestations, including seizure complexity, while controlling for etiology and lesion location.
This study retrospectively analyzed clinical data from patients who underwent anterior temporal lobectomy (ATL) and achieved seizure-free at Sanbo Brain Hospital. Semiological features were analyzed using video-electroencephalogram (video-EEG) recordings. Following descriptive analysis of clinical characteristics and seizure symptom differences between children and adult cohorts, univariate and multivariate logistic regression analyses were performed to evaluate associations between clinical variables and specific seizure components.
A total of 176 patients (39 children and 137 adults) who underwent ATL and achieved seizure-free status met the inclusion criteria for this study. Significant differences were observed between children and adults in the incidence of: auras (), motor seizures (), clonic seizures (), focal to bilateral tonic-clonic seizures (), and lateralizing signs (). The incidence of automotor seizures () and clonic seizures () showed a positive correlation with increasing age.
This study demonstrates significant age-dependent differences in semiological manifestations of TLE, suggesting that age-related neurodevelopmental changes underlie distinct seizure patterns. These findings support age-specific treatment strategies, as age affects TLE seizure patterns and clinical management decisions.
本研究调查了儿童和成人颞叶癫痫（TLE）的症状学特征差异，特别考察了年龄对这些表现的影响。本研究使用多变量分析，在控制病因和病变位置的同时，评估年龄对TLE临床表现（包括发作复杂性）的影响。
本研究回顾性分析了在三博脑科医院接受前颞叶切除术（ATL）并实现无发作的患者的临床数据。使用视频脑电图（video-EEG）记录分析症状学特征。在对儿童和成人队列的临床特征和癫痫发作症状差异进行描述性分析之后，进行单变量和多变量逻辑回归分析，以评估临床变量与特定癫痫发作成分之间的关联。
共有176例接受ATL并达到无发作状态的患者符合本研究的纳入标准。在先兆（）、运动性癫痫发作（）、阵挛性癫痫发作（）、局灶性至双侧强直阵挛性癫痫发作（）和定位体征（）的发生率方面，儿童和成人之间观察到显著差异。自动运动性癫痫发作（）和阵挛性癫痫发作（）的发生率与年龄增长呈正相关。
本研究表明TLE的症状学表现存在显著的年龄依赖性差异，提示与年龄相关的神经发育变化是不同癫痫发作模式的基础。这些发现支持针对不同年龄的治疗策略，因为年龄会影响TLE的癫痫发作模式和临床管理决策。
