一例伴有残余胰岛素分泌的暴发性1型糖尿病病例。
A Case of Fulminant Type 1 Diabetes With Residual Insulin Secretion.
作者信息
Kato Tomoko, Harada Norio, Nishikawa Yuki, Yamamoto Kana, Murakami Takaaki, Ueda Yohei, Okamoto Motozumi, Yabe Daisuke
机构信息
Diabetes, Endocrinology, and Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, JPN.
Endocrinology and Metabolism, University of Fukui School of Medical Sciences, Fukui, JPN.
出版信息
Cureus. 2025 Apr 21;17(4):e82751. doi: 10.7759/cureus.82751. eCollection 2025 Apr.
A 67-year-old woman presented with fever and a cold a week later, with symptoms of hyperglycemia. After 10 days, her non-fasting blood glucose level was 586 mg/dL, and glycosylated hemoglobin (HbA1c) was 7.2%. She then developed diabetic ketosis and was treated with insulin. Her fasting C-peptide immunoreactivity (CPR) became 0.4 ng/mL. However, her insulin requirement was subsequently reduced. After two months, her CPR was 1.07 ng/mL at zero minutes and 2.04 ng/mL at six minutes in a glucagon stimulation test. Daily urinary CPR was 62 mg. Even though fulminant type 1 diabetes was indicated from the clinical course, insulin secretory ability improved.
一名67岁女性一周后出现发热和感冒，并伴有高血糖症状。10天后，她的非空腹血糖水平为586mg/dL，糖化血红蛋白（HbA1c）为7.2%。随后她发展为糖尿病酮症，并接受胰岛素治疗。她的空腹C肽免疫反应性（CPR）降至0.4ng/mL。然而，她随后的胰岛素需求量减少。两个月后，在胰高血糖素刺激试验中，她的CPR在零分钟时为1.07ng/mL，六分钟时为2.04ng/mL。每日尿CPR为62mg。尽管从临床病程来看提示为暴发性1型糖尿病，但胰岛素分泌能力有所改善。
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