Rad Bodan Roxana Cristina, Dușe Adina Octavia, Papp Eniko Gabriela, Melinte Răzvan Marian, Andor Minodora
Doctoral School, Victor Babeş University of Medicine and Pharmacy, No. 2 Eftimie Murgu Square, 300041 Timișoara, Romania.
Department of Balneofiziokinetotherapy and Medical Recovery, Faculty of Medicine, Dimitrie Cantemir University Târgu-Mureș, No. 3-5 Bodoni Sandor, 540545 Târgu-Mureș, Romania.
J Funct Morphol Kinesiol. 2025 Apr 28;10(2):150. doi: 10.3390/jfmk10020150.
: Hypertension is in first place in Europe among cardiovascular diseases. Worldwide, only 1 in 5 adults pursue proper treatment that controls their high blood pressure. Endothelial dysfunction is a marker that indicates the progression of hypertension. The study aims to evaluate the efficacy of antihypertensives and physical and hydrotherapy cardiovascular rehabilitation programs to control hypertension and improve endothelial dysfunction. : A total of 100 patients with hypertension degree 1 (46 years ± 0.32) were divided into four homogenic groups. All subjects of the A, B, C and D groups benefited from recommendations for a healthy lifestyle; groups B, C and D also received antihypertensive medication; additionally, group C had a physical cardiovascular program and group D a cardiovascular hydrotherapy program. Several clinical endothelial damage markers and blood and urine parameters were registered, along with systolic and diastolic blood pressure, before and after 8 weeks of rehabilitation. : Group A registered a statistically significant decrease for 1 parameter LDL ( = 0.002). Group B showed statistically significant values for 14 parameters ( ≤ 0.05). The C and D groups registered significantly improved statistic values for 17 parameters each ( ≤ 0.0001). : Groups B, C and D that were given antihypertensive medication during rehabilitation registered improved endothelial dysfunctional markers and controlled blood pressure values, compared with group A which was given only recommendations for a healthy lifestyle.
在欧洲，高血压在心血管疾病中位居首位。在全球范围内，只有五分之一的成年人接受能控制其高血压的适当治疗。内皮功能障碍是表明高血压进展的一个指标。该研究旨在评估抗高血压药物以及物理和水疗心血管康复项目在控制高血压和改善内皮功能障碍方面的疗效。
共有100名1级高血压患者（46岁±0.32）被分为四个同质组。A、B、C和D组的所有受试者都受益于健康生活方式建议；B、C和D组还接受了抗高血压药物治疗；此外，C组有一个物理心血管项目，D组有一个心血管水疗项目。在康复8周前后，记录了几个临床内皮损伤标志物以及血液和尿液参数，还有收缩压和舒张压。
A组有1个参数低密度脂蛋白（LDL）出现了具有统计学意义的下降（P = 0.002）。B组有14个参数出现了具有统计学意义的值（P≤0.05）。C组和D组各有17个参数的统计值有显著改善（P≤0.0001）。
与仅接受健康生活方式建议的A组相比，在康复期间接受抗高血压药物治疗的B、C和D组的内皮功能障碍标志物得到改善，血压值得到控制。
