Blanton Lucas S, Muir Sarah E, Mendell Nicole L, Walker David H
Department of Internal Medicine-Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA.
John Sealy School of Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
Infect Dis Rep. 2025 May 1;17(3):45. doi: 10.3390/idr17030045.
Spotted fever group (SFG) rickettsioses are tick-transmitted infections caused by Gram-negative, obligately intracellular bacteria in the genus . They present as an acute undifferentiated febrile illness, and they are often accompanied by rash and/or eschar. Although the rash of SFG rickettsioses usually consists of macules and papules, some, like in rickettsiosis, can also manifest with papulovesicular or pustular lesions. We herein present a case of SFG rickettsiosis, due to , that masqueraded as Sweet syndrome (the prototype neutrophilic dermatosis) after the initial results of a shave biopsy. Further investigation of the biopsy specimen by immunohistochemical and PCR analysis would eventually confirm SFG rickettsiosis, with being detected by real-time PCR. is transmitted by the Gulf Coast tick () and is an increasingly recognized cause of SFG rickettsiosis in the United States. should be considered in those with an acute undifferentiated febrile illness with lesions that are pustular or papulovesicular, as prompt recognition and empirical administration of doxycycline results in the rapid resolution of symptoms.
斑点热群（SFG）立克次体病是由革兰氏阴性、专性细胞内细菌引起的蜱传播感染。它们表现为急性未分化发热性疾病，常伴有皮疹和/或焦痂。虽然SFG立克次体病的皮疹通常由斑疹和丘疹组成，但有些，如立克次体病，也可表现为丘疹水疱或脓疱性病变。我们在此报告一例由[病原体名称]引起的SFG立克次体病病例，该病例在刮除活检初步结果后伪装成Sweet综合征（典型的嗜中性皮病）。通过免疫组织化学和PCR分析对活检标本进行进一步调查最终确诊为SFG立克次体病，实时PCR检测到[病原体名称]。[病原体名称]由墨西哥湾沿岸蜱（[蜱的名称]）传播，在美国是SFG立克次体病日益被认识到的病因。对于患有急性未分化发热性疾病且有脓疱或丘疹水疱性病变的患者，应考虑[病原体名称]感染，因为及时识别并经验性给予多西环素可使症状迅速缓解。
