[4,6-二取代吡唑并(3,4-d)嘧啶对红细胞嘌呤核苷磷酸化酶催化鸟苷砷解反应的失活作用]
[Inactivation by 4,6 disubstituted pyrazolo (3,4-d) pyrimidines of the arsenolysis of guanosine by erythrocyte purine nucleoside phosphorylase].
作者信息
Thang K V, Delbarre F, Auscher C, Gerbaut L
出版信息
C R Acad Hebd Seances Acad Sci D. 1977 Feb 7;284(6):481-3.
PMID:404078
Abstract
New drugs are proposed in an attempt to reduce the overformation of uric acid in man. The procedure is based on the inhibition of human purine nucleoside phosphorylase selectively investigated in its phosphorolytic sequence. But for technical reasons, analogous inactivation of the enzyme in its comparative guanosine arsenolysis is subject to experimentation.
摘要
人们提出了新的药物，试图减少人体内尿酸的过度生成。该方法基于对人类嘌呤核苷磷酸化酶在其磷酸解序列中的选择性抑制进行研究。但由于技术原因，该酶在其比较性鸟苷砷解中的类似失活仍在实验中。
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[Inactivation by 4,6 disubstituted pyrazolo (3,4-d) pyrimidines of the arsenolysis of guanosine by erythrocyte purine nucleoside phosphorylase].[4,6-二取代吡唑并(3,4-d)嘧啶对红细胞嘌呤核苷磷酸化酶催化鸟苷砷解反应的失活作用]
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