Benade Vijay S, Jayarajan Pradeep, Krishnadas Nandakumar, Nirogi Ramakrishna
Suven Life Sciences, Serene Chambers, Road # 7, Banjara Hills, Hyderabad, 500 034, India.
Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, India.
Naunyn Schmiedebergs Arch Pharmacol. 2025 May 23. doi: 10.1007/s00210-025-04290-w.
Neurodegenerative diseases, such as Alzheimer's diseases (AD), are becoming more prevalent as population ages. Recent researches indicate possible involvement of increased oxidative stress and free radicals in AD-related changes, suggesting that therapeutic efforts aimed at the removal of reactive oxygen species (ROS) or prevention of their formation may be beneficial in AD. Resveratrol, a polyphenol found in red wines, demonstrated antioxidant and anti-aging effects in various in vitro and in vivo studies. In the current work, resveratrol was evaluated in animal model of cognitive impairment and/or neurodegeneration as a potential treatment approach for AD. Rats were treated with aluminum chloride (AlCl) for 20 days for induction of oxidative stress and simultaneously with resveratrol (15 and 30 mg/kg, p.o.). Animals were subjected for assessment of working memory, modulations in biomarkers related to oxidative stress, cognition and sirtuin-1 levels. Impaired cognitive abilities and increased oxidative stress were observed in rats treated with AlCl alone; however, resveratrol significantly improved cognitive performance, decreased oxidative stress and increased levels of antioxidant enzymes along with biomarkers related to cognition and anti-aging. Results from current studies indicate that due to its anti-aging and antioxidant properties, resveratrol may have a potential in pharmacotherapy of neurodegenerative disorder such as AD.
随着人口老龄化，神经退行性疾病，如阿尔茨海默病（AD），正变得越来越普遍。最近的研究表明，氧化应激增加和自由基可能参与了与AD相关的变化，这表明旨在清除活性氧（ROS）或预防其形成的治疗措施可能对AD有益。白藜芦醇是一种存在于红酒中的多酚，在各种体外和体内研究中都显示出抗氧化和抗衰老作用。在当前的工作中，对认知障碍和/或神经退行性变动物模型中的白藜芦醇进行了评估，作为AD的一种潜在治疗方法。用氯化铝（AlCl）处理大鼠20天以诱导氧化应激，同时给予白藜芦醇（15和30mg/kg，口服）。对动物进行工作记忆评估、与氧化应激、认知和沉默调节蛋白-1水平相关的生物标志物的调节评估。单独用AlCl处理的大鼠出现认知能力受损和氧化应激增加；然而，白藜芦醇显著改善了认知表现，降低了氧化应激，并提高了抗氧化酶水平以及与认知和抗衰老相关的生物标志物水平。当前研究结果表明，由于其抗衰老和抗氧化特性，白藜芦醇可能在AD等神经退行性疾病的药物治疗中具有潜力。
