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DNA甲基化及其对多囊卵巢综合征女性卵巢类固醇生成的影响：来自人类和动物模型的见解

DNA methylation and its impact on ovarian steroidogenesis in women with polycystic ovary syndrome: insights from human and animal models.

作者信息

Zhong Yanyu, Ding Jin, Xia Fei

机构信息

Reproductive Medicine Centre, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215000, People's Republic of China.

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215000, People's Republic of China.

出版信息

Arch Gynecol Obstet. 2025 May 23. doi: 10.1007/s00404-025-08048-w.

DOI:10.1007/s00404-025-08048-w
PMID:40407877
Abstract

PURPOSE

To review how DNA methylation affects ovarian steroidogenesis in polycystic ovary syndrome (PCOS), with evidence from human and animal studies.

RECENT FINDINGS

Women with PCOS show global DNA hypomethylation and altered methylation of ovarian steroidogenic genes, contributing to hyperandrogenism. Animal models of PCOS mirror these epigenetic changes and support a causal role, highlighting DNA methylation signatures as diagnostic biomarkers and therapeutic targets.

摘要

目的

借助来自人体和动物研究的证据，综述DNA甲基化如何影响多囊卵巢综合征（PCOS）中的卵巢类固醇生成。

最新发现

PCOS女性表现出全基因组DNA低甲基化以及卵巢类固醇生成基因的甲基化改变，这导致了高雄激素血症。PCOS动物模型反映了这些表观遗传变化，并支持因果关系，突出了DNA甲基化特征作为诊断生物标志物和治疗靶点的作用。

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本文引用的文献

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Caloric restriction prevents inheritance of polycystic ovary syndrome through oocyte-mediated DNA methylation reprogramming.热量限制通过卵母细胞介导的DNA甲基化重编程预防多囊卵巢综合征的遗传。
Cell Metab. 2025 Apr 1;37(4):920-935.e6. doi: 10.1016/j.cmet.2025.01.014. Epub 2025 Feb 21.
2
The regulatory interplay between miRNA and DNA methylation orchestrates vital ovarian functions and associated traits in PCOS.微小RNA（miRNA）与DNA甲基化之间的调控相互作用协调了多囊卵巢综合征（PCOS）中至关重要的卵巢功能及相关特征。
Gene. 2025 Mar 10;940:149165. doi: 10.1016/j.gene.2024.149165. Epub 2024 Dec 15.
3
Whispers of the polycystic ovary syndrome theater: Directing role of long noncoding RNAs.
多囊卵巢综合征舞台的低语：长链非编码RNA的主导作用
Noncoding RNA Res. 2024 May 14;9(4):1023-1032. doi: 10.1016/j.ncrna.2024.05.003. eCollection 2024 Dec.
4
Gut hormone multi-agonists for the treatment of type 2 diabetes and obesity: advances and challenges.肠促胰素多重激动剂治疗 2 型糖尿病和肥胖症：进展与挑战。
J Endocrinol. 2024 Jul 22;262(3). doi: 10.1530/JOE-23-0404. Print 2024 Sep 1.
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Liraglutide alleviates experimental diabetic cardiomyopathy in a PDH-dependent manner.利拉鲁肽通过 PDH 依赖性途径减轻实验性糖尿病心肌病。
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6
Maternal androgen exposure induces intergenerational effects via paternal inheritance.母体雄激素暴露通过父系遗传诱导跨代效应。
J Endocrinol. 2024 Jun 24;262(2). doi: 10.1530/JOE-23-0368. Print 2024 Aug 1.
7
Polycystic ovary syndrome.多囊卵巢综合征。
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8
Epigenetic/circadian clocks and PCOS.表观遗传/昼夜节律钟与 PCOS。
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