Lv Mei, Feng Anni, Cheng Di, Xu Zejun, Xie Yuanjie, Tu Jian
Hunan Province Innovative Training Base for Medical Postgraduates, Yueyang Maternal and Child Health Hospital, Yueyang, 414000, Hunan, China.
Anshun City People's Hospital, Anshun, 561000, Guizhou, China.
Reprod Sci. 2025 May 23. doi: 10.1007/s43032-025-01879-7.
Polycystic ovary syndrome (PCOS) is a common and frequent disease and always leads to endocrine and metabolic disorders among women of reproductive age. In most PCOS patients, the serum level of anti-mullerian hormone (AMH) is significantly higher than that of normal women of childbearing age. AMH is an important auxiliary diagnostic method for PCOS. AMH may play an important role in the occurrence and development of PCOS and potentially affect the success of in vitro fertilization (IVF) treatments, although the exact mechanisms remain unclear. This review focuses on the relationships and mechanisms of dysregulated AMH and follicular development in PCOS based on recent research. It is mainly manifested in the regulation of related signal pathways, the negative feedback regulatory loop of several gonadal hormones such as follicle-stimulating hormone, luteinizing hormone, estradiol, and testosterone, as well as the influence of AMH on IVF in PCOS patients. Additionally, it puts forward some suggestions, which will provide some helpful ideas or directions for future further research on PCOS.
多囊卵巢综合征（PCOS）是一种常见且频发的疾病，常导致育龄期女性出现内分泌和代谢紊乱。在大多数PCOS患者中，抗苗勒管激素（AMH）的血清水平显著高于正常育龄期女性。AMH是PCOS的一种重要辅助诊断方法。尽管确切机制尚不清楚，但AMH可能在PCOS的发生发展中起重要作用，并可能影响体外受精（IVF）治疗的成功率。本综述基于近期研究，聚焦于PCOS中AMH失调与卵泡发育的关系及机制。主要体现在相关信号通路的调控、卵泡刺激素、黄体生成素、雌二醇和睾酮等几种性腺激素的负反馈调节环路，以及AMH对PCOS患者IVF的影响。此外，还提出了一些建议，这将为未来进一步研究PCOS提供一些有益的思路或方向。
