Nishimura Haruki, Layne Jonathan, Yamaura Kohei, Marcucio Ralph, Morioka Kazuhito, Basbaum Allan I, Weinrich Jarret A P, Bahney Chelsea S
Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, CO, United States.
Department of Orthopaedic Surgery, University Hospital of Occupational and Environmental Health, Fukuoka, Japan.
Pain. 2025 May 21. doi: 10.1097/j.pain.0000000000003646.
Pain is one of the primary indicators of a bone fracture and serves both a functional and practical role in guiding recovery. However, fracture pain can persist long after the fracture itself has clinically healed. The neural and molecular mechanisms that drive acute pain postfracture, and how these mechanisms are pathologically usurped to trap patients into persistent, debilitating, and often difficult to treat, chronic pain, are not well understood. The aim of this review is to provide insight into the risk factors for pain persistence after fracture, review the physiological and pathophysiological mechanisms of fracture pain, and critically evaluate the literature around fracture pain assessment techniques/models. Taken together, the concepts covered herein will provide a strong foundation to support the development of more effective treatments to better alleviate postfracture pain.
疼痛是骨折的主要指标之一，在指导康复过程中兼具功能和实际作用。然而，骨折疼痛可能在骨折本身临床愈合后仍长期存在。导致骨折后急性疼痛的神经和分子机制，以及这些机制如何在病理上被篡夺，使患者陷入持续的、使人衰弱且往往难以治疗的慢性疼痛，目前尚不清楚。本综述的目的是深入了解骨折后疼痛持续的危险因素，回顾骨折疼痛的生理和病理生理机制，并严格评估有关骨折疼痛评估技术/模型的文献。综上所述，本文涵盖的概念将为支持开发更有效的治疗方法以更好地缓解骨折后疼痛提供坚实基础。
