Algellay Marwan, Sarker Satyajit D, Roberts Matthew, Bosworth Lucy A, Ehtezazi Touraj
School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom.
Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, United Kingdom.
J Pharm Pharmacol. 2025 May 23. doi: 10.1093/jpp/rgaf028.
Additive manufacturing is a renowned technology for producing three-dimensional objects, based on ceramic, metal, and plastic materials for different applications. This review examines and provides a perspective on using nanomaterials along with biopolymeric matrices for 3D printing (3DP) with potential applications in pharmaceutical dosage forms. Many 3DP methods have been developed for the formulation of drug delivery systems, including stereolithography, fused deposition modelling (FDM), selective laser sintering, and bioprinting through droplet- or extrusion-assisted techniques. Polymeric drug-loaded nanocapsules regulated the drug release profiles from 3D-printed tablets with faster drug release from 50% infill tablets. Also, incorporating nanomaterials/micro-ribbons significantly changed the mechanical and flow properties of polymers used in 3DP. For example, the addition of 1% w/w chitosan micro-ribbons to poly-vinyl alcohol powder improved filament mechanical properties for FDM 3DP in terms of flexibility and stiffness, with enhanced disintegration time of 3D-printed oral films. Berberine nanoparticles were integrated into a biodegradable and biocompatible 3D-printed pill, which facilitated sustained drug release and improved gastrointestinal absorption. Furthermore, nanocrystals enhanced the solubility of 3D-printed oral films. In conclusion, nanocomposites improved 3D-printed drug delivery systems in different aspects such as mechanical strength, solubility, and drug release profiles.
增材制造是一种用于生产三维物体的知名技术，它基于陶瓷、金属和塑料材料，适用于不同的应用。本文综述并探讨了在3D打印（3DP）中使用纳米材料与生物聚合物基质相结合的情况，及其在药物剂型中的潜在应用。人们已经开发出许多3DP方法用于药物递送系统的制剂，包括立体光刻、熔融沉积建模（FDM）、选择性激光烧结以及通过液滴或挤出辅助技术进行的生物打印。载药聚合物纳米胶囊调节了3D打印片剂的药物释放曲线，50%填充率的片剂药物释放更快。此外，加入纳米材料/微带显著改变了3DP中使用的聚合物的机械性能和流动性能。例如，向聚乙烯醇粉末中添加1%w/w的壳聚糖微带，在柔韧性和刚度方面改善了FDM 3DP的长丝机械性能，同时延长了3D打印口腔薄膜的崩解时间。黄连素纳米颗粒被整合到一种可生物降解且生物相容的3D打印药丸中，这有助于药物持续释放并改善胃肠道吸收。此外，纳米晶体提高了3D打印口腔薄膜的溶解度。总之，纳米复合材料在机械强度、溶解度和药物释放曲线等不同方面改善了3D打印药物递送系统。
