Jin'o Yusuke, Ushikai Miharu, Komaki Yuga, Masuda Koichi, Horiuchi Masahisa
Momiji Pharmacy, Yoshishige Pharmacy Group, Kagoshima, Japan.
Kagoshima City Pharmaceutical Association, Kagoshima, Japan.
PLoS One. 2025 May 23;20(5):e0322879. doi: 10.1371/journal.pone.0322879. eCollection 2025.
Colorectal cancer (CRC) is the third most common malignancy and second leading cause of death worldwide. However, the screening rate, which is a typical preventive measure, remains low. A community pharmacy pharmacist (CPP)-mediated procedure was used to increase the CRC screening rate. A total of 37 community pharmacies in Kagoshima, a core city in Japan, participated in this study. The results were statistically compared with the results of two procedures in Kagoshima City: hospital/clinic institution-mediated and health examination institution-mediated procedures. The cost was set at 1,100 JPY to perform a fecal immunochemical test, considering the costs as the self-payment of the other two procedures. In March 2023, 2,611 kits were distributed, and 273 tests were conducted under the research conditions. A significantly higher percentage of people in their 40s were tested using CPP-mediated procedures (35.2% vs. 14.3% in the hospital/clinic, and 21.8% in the health examination institution, respectively, p < 0.01). The percentage of participants who underwent a detailed examination at CPP facilities was significantly lower than in the other two groups (46.7% vs. 87.3% in the hospital/clinic, and 83.0% in the health examination institution, p < 0.05). In the CPP-mediated procedure, the test result turn-around time was approximately one day. Although a 2-day method was used, the implementation rate was 100%. The CPP-mediated procedure did not differ significantly from hospital/clinic or health examination institution procedures in terms of the number of detailed examination findings. In particular, the CPP-mediated procedure may address gaps by increasing the number of young people and people with reduced opportunities who receive CRC screening. The CPP-mediated procedure could be implemented as a new procedure with certain advantages. Moreover, it should be considered that this procedure can be implemented and sustained in society without government support.
结直肠癌（CRC）是全球第三大常见恶性肿瘤，也是第二大死亡原因。然而，作为一种典型预防措施的筛查率仍然很低。采用了社区药房药剂师（CPP）介导的程序来提高CRC筛查率。日本核心城市鹿儿岛的37家社区药房参与了本研究。将结果与鹿儿岛市另外两种程序的结果进行统计学比较：医院/诊所机构介导和健康检查机构介导的程序。考虑到其他两种程序的自付费用，进行粪便免疫化学检测的成本设定为1100日元。2023年3月，分发了2611套检测试剂盒，在研究条件下进行了273次检测。在40多岁的人群中，使用CPP介导程序进行检测的比例显著更高（分别为35.2%，而医院/诊所为14.3%，健康检查机构为21.8%，p<0.01）。在CPP机构接受详细检查的参与者比例显著低于其他两组（46.7%，而医院/诊所为87.3%，健康检查机构为83.0%，p<0.05）。在CPP介导的程序中，检测结果周转时间约为一天。虽然采用了2天的方法，但其实施率为100%。在详细检查结果数量方面，CPP介导的程序与医院/诊所或健康检查机构的程序没有显著差异。特别是，CPP介导的程序可能通过增加接受CRC筛查的年轻人和机会减少的人群数量来弥补差距。CPP介导的程序可以作为一种具有一定优势的新程序来实施。此外，应该考虑到该程序可以在没有政府支持的情况下在社会中实施和持续开展。
