Farajnia Sara, Rajabi Hamid, Ghaffari Mehran, Beladi-Moghadam Nahid, Fayazmilani Rana
Department of Biological Sciences in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, , Iran.
Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, Kharazmi University, Tehran, Iran.
Mult Scler Relat Disord. 2025 Jul;99:106412. doi: 10.1016/j.msard.2025.106412. Epub 2025 May 22.
This study investigates how combined aerobic-cognitive training and aerobic training impact some symptoms of MS.
Thirty RRMS patients with EDSS≤ 4 were randomly assigned to three groups: Brythonic training, aerobic training, and control. The training groups participated in ten weeks of home-based online training. The Brythonic group performed aerobic movements while reciting motivational words. The aerobic group performed the same movements without cognitive tasks. Interleukin 17 (IL-17), Interleukin 4 (IL-4), and Interleukin 17 to Interleukin 4 ratio (IL-4/IL-17), Time Up and Go (TUG) and Six-Minute Walk Test (6MWT), Modified Fatigue Impact Scale (MFIS), Multiple Sclerosis Quality of Life-54 Questionnaires (MSQOL-54) were measured before and after the 10-week.
The Interleukin 17 variable significantly decreased in the Brythonic (P < 0.0001). Nevertheless, Interleukin 4 and the Interleukin 17 and 4 ratios did not significantly differ. TUG and 6MWT variables substantially differed in training groups compared to the control. In MFIS, a significant difference was observed between the training and control groups. The MSQOL-54 variable substantially differed in mental health items in the Brythonic compared to the control group and in physical health items a significant difference was observed between the training and the control groups. Notably, in all the variables except the Interleukin 4 variable, the Brythonic significantly improved the results within the group.
This study concluded that engaging in any aerobic activity, even with moderate intensity, can improve some symptoms of MS such as fatigue and physical performance. Additionally, incorporating cognitive challenges into aerobic activity can cause a more significant effect, specifically on inflammatory factors.
本研究调查有氧认知训练与有氧训练相结合如何影响多发性硬化症的某些症状。
30名扩展残疾状态量表（EDSS）≤4的复发缓解型多发性硬化症（RRMS）患者被随机分为三组：布莱森训练组、有氧训练组和对照组。训练组参加为期十周的居家在线训练。布莱森训练组在背诵激励性话语的同时进行有氧运动。有氧训练组进行相同的运动但无认知任务。在为期10周的训练前后，测量白细胞介素17（IL - 17）、白细胞介素4（IL - 4）、白细胞介素17与白细胞介素4的比值（IL - 4/IL - 17）、起立行走测试（TUG）、六分钟步行测试（6MWT）、改良疲劳影响量表（MFIS）、多发性硬化症生活质量54项问卷（MSQOL - 54）。
布莱森训练组中白细胞介素17变量显著降低（P < 0.0001）。然而，白细胞介素4以及白细胞介素17与4的比值无显著差异。与对照组相比，训练组的TUG和6MWT变量有显著差异。在MFIS方面，训练组与对照组之间存在显著差异。与对照组相比，布莱森训练组在MSQOL - 54变量的心理健康项目上有显著差异，在身体健康项目上，训练组与对照组之间也存在显著差异。值得注意的是，除白细胞介素4变量外，在所有变量中，布莱森训练组在组内均显著改善了结果。
本研究得出结论，进行任何有氧运动，即使强度适中，都可以改善多发性硬化症的某些症状，如疲劳和身体机能。此外，将认知挑战纳入有氧运动可产生更显著的效果，特别是对炎症因子。
